Senior / Principal Scientist

Austin Fraser; England; On-site; GBP 40,000 - 60,000; Full time

Job summary

A leading company in cancer immunotherapy seeks a skilled scientist to drive T-cell receptor engineering processes. The role involves validation, protein purification, and collaboration with cross-disciplinary teams. Candidates must hold a PhD and have relevant lab experience to tackle challenging immunotherapy projects.

Benefits

Market-competitive salary and stock options

25 days holiday plus public holidays and a birthday day off

Access to a private lab

Qualifications

• 1-2 years of relevant lab experience required; over 3 years for senior roles.
• Experience in in vivo and in vitro validation of TCEs is critical.
• Knowledge of molecular biology protocols preferred.

Responsibilities

• Lead in vivo and in vitro validation of TCEs.
• Conduct protein science operations including purification and analysis.
• Manage tissue culture assignments and uphold lab protocols.

Skills

Molecular biology protocols

Cloning

Protein expression

Purification

Biophysical characterization

Flow cytometry

ELISA

NGS analysis

Data analysis using R

Education

PhD in Immunology, Cell Biology, or Biochemistry

Job description

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Help drive the TCR engineering processes and development by leading in vivo and in vitro validation of TCEs. You'll get involved in purifying recombinant TCRs to perform high-throughput TCR display methods and deep sequencing.

Client Details

The client are reimagining what's possible in cancer immunotherapy. Our mission is to engineer T-cell receptor therapies that can precisely and powerfully target solid tumours-diseases long considered out of reach for conventional immunotherapies.

Description

Lead in vivo and in vitro validation of TCEs.
Collaboratively design and characterise TCRs for proprietary and partnered disease targets.
Conduct a suite of protein science operations, including expression, purification, and biophysical analysis.
Tackle molecular biology duties: cloning, mutagenesis, DNA isolation, and preparing libraries for deep sequencing.
Manage tissue culture assignments, spanning from media prep and cell line care to cryopreservation.
Join forces with founders, R&D, academia, and industrial stakeholders to fulfil ambitious R&D objectives.
Draft, revise, and oversee repertoire of lab protocols.
Offer essential lab support and uphold facility upkeepProfile

PhD in Immunology, Cell Biology, Biochemistry, or an alike field, paired with at least 1-2 years of relevant lab experience is required.
For senior scientist we are looking for over 3 years industry experience.
Experience in in vivo and in vitro validation of TCEs (T-cell engagers) all the way though to investigational new drug (IND) approval is critical Knowledge of molecular biology protocols, with an emphasis on cloning and PCR is preferred.
A background in protein expression, purification and biophysical characterisation is preferred.
Experience in cell and immunological assays (flow cytometry, ELISA etc.) is desired.
Experience in NGS analysis pipeline (specifically data analysis using software such as R) is desired.
SOP documentation experience is desired.Job Offer

Market-competitive salary and stock option package.
A generous leave policy: 25 days holiday, public holidays, plus a day off for your birthday!
Access to fully equipped private lab.
Flexibility to work from home as project demands allow.
A supportive, cross-disciplinary team fostering a highly collaborative work environment