Senior Principal Data Scientist

Novartis; London; On-site; GBP 100,000 - 130,000; Full time

Job summary

A leading pharmaceutical company is searching for a Senior Principal Data Scientist to join their Multimodal Data and Analytics group in London. This role involves analyzing high-dimensional patient-level data to inform clinical development and strategic decisions in drug development, requiring a strong background in statistics and data science.

Qualifications

• 5+ years experience in the pharma/biotech industry with MS or 2+ years with PhD.
• Good understanding of clinical study design and working with clinical data.
• Strong knowledge of statistical methods, machine learning, and multivariate analysis.

Responsibilities

• Support high-dimensional analyses of patient-level data for clinical programs.
• Collaborate with teams to design and execute biomarker strategies.
• Perform hands-on analysis of integrated clinical and biomarker data.

Skills

Collaboration

Quantitative Analysis

Statistical Concepts

Data Visualization

Education

Advanced degree in bioinformatics, statistics, or data science

Tools

R

Python

Job description

Join to apply for the Senior Principal Data Scientist role at Novartis

Join to apply for the Senior Principal Data Scientist role at Novartis

Summary

The Multimodal Data and Analytics group is searching for a Principal Data Scientist. As the successful candidate, you will support the application of high-dimensional analyses of patient level data (including various -omics, phenomics, IHC, MRI, clinical and outcomes data) to mid to late development clinical programs in one or more indications. You will be part of interdisciplinary teams that analyze and interpret biomarker data to inform critical project decisions, regulatory submissions and directly influence drug development decisions with internal and external partners.

Summary

The Multimodal Data and Analytics group is searching for a Principal Data Scientist. As the successful candidate, you will support the application of high-dimensional analyses of patient level data (including various -omics, phenomics, IHC, MRI, clinical and outcomes data) to mid to late development clinical programs in one or more indications. You will be part of interdisciplinary teams that analyze and interpret biomarker data to inform critical project decisions, regulatory submissions and directly influence drug development decisions with internal and external partners.

About The Role

Principal Data Science, Multimodal Data & Analytics in Clinical Development

200+ compounds are supported by the quantitative drug developers at Novartis Development Analytics. We focus on transforming data from multiple (multimodal) sources - clinical, -omics, imaging - into analyses and insights that build the basis for making innovative drugs accessible for patients. We influence decision-making in cross-functional international teams from mid to late phase drug development.

The Multimodal Data and Analytics group is searching for a Principal Data Scientist. As the successful candidate, you will support the application of high-dimensional analyses of patient level data (including various biomarker, clinical and outcomes data) to mid to late development clinical programs in one or more indications. You will be part of interdisciplinary teams that analyze and interpret biomarker data to inform critical project decisions and understand mechanisms of response/resistance to therapy. You will contribute to the design and execution of the biomarker strategy in those programs to inform drug development, and you will contribute to the strategy for addressing biomarker issues in late phase trials, regulatory submissions and directly influence drug development decisions with internal and external partners. The focus is less on method development or discovery, but on combining your domain knowledge of drug development, trials and biology with cutting-edge methodologies (ranging from survival models to machine learning) and technologies (imaging and multi-omics) to create tangible impact on clinical trials and patients.

Key Requirements

• Ability to collaborate with cross-functional partners, provide quantitative, scientific and strategic input to support the execution of the integrated biomarker strategies in drug development that facilitate internal decision making, and support submissions of candidate drug.
• Ability to explain statistical concepts in an easily understandable way to non-statisticians and provide adequate statistical justifications and interpretation of analysis results for actions/decisions/statements, when required.
• Performing hands-on analysis of integrated clinical, outcomes and high-dimensional, patient-level biomarker data from clinical trials (genomics, transcriptomics, proteomics, flow cytometry etc.) to generate fit-for-purpose evidence that is applied for decision making in drug development programs.
  
  

Essential Requirements

• Advanced degree in bioinformatics, statistics, data science or other quantitative discipline with extensive exposure to clinical trials and drug development. MS with 5+ years relevant work experience or PhD with 2+ years of relevant work experience in the pharma/biotech industry
• Good understanding of clinical study design principles and basic familiarity working with clinical data in a clinical trial (GxP) setting
• Strong knowledge and understanding of (multivariate implementations of) statistical methods such as time to event analysis, machine learning, meta-analysis, mixed effect modeling, longitudinal modeling, Bayesian methods, variable selection methods (e.g., lasso, elastic net, random forest), design of clinical trials.
• Familiarity with statistical and analytical methods for genetics and -omics data analysis and working knowledge of high dimensional biomarker platforms (e.g., next generation sequencing, transcriptomics, proteomics, flow cytometry, etc.).
• Strong programming skills in R and Python. Demonstrated knowledge of data visualization, exploratory analysis and predictive modeling.
• Ability to leverage technical and scientific information from a variety of sources in order to effectively enable data analysis and the scientific interpretation of analysis results.
• Ability to develop and deliver clear and concise presentations for both internal and external meetings in key decision-making situations.
  
  

Desirable Requirements

• Experience with modern data science methods and designing machine learning or other AI architectures for applications in healthcare
• Additional expertise in big data, web-based applications, good coding practice, source code management (Git, bitbucket)
• Exposure to and hands-on experience with various forms of RWE is a plus.
  
  

Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting, and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? : https://www.novartis.com/about/strategy/people-and-culture

Commitment To Diversity & Inclusion

Novartis is committed to building an outstanding, inclusive work environment and diverse team’s representative of the patients and communities we serve.

Join Our Novartis Network

Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network

Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture

Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network

Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Seniority level

• Seniority level

  Mid-Senior level

Employment type

• Employment type

  Full-time

Job function

• Job function

  Engineering and Information Technology

• Industries

  Pharmaceutical Manufacturing

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