Senior PKPD Modeller

JR United Kingdom; Warrington; On-site; GBP 65,000 - 90,000; Full time

Job summary

A leading pharmaceutical company is seeking a Senior PK/PD Modeller to join their Clinical Pharmacology team in Warrington. The role involves designing and implementing pharmacokinetic/pharmacodynamic modeling strategies to support drug development. Candidates should hold a PhD or similar and have substantial modeling experience. This position offers a competitive salary and the opportunity to work in a collaborative and innovative environment.

Benefits

Competitive salary

Comprehensive benefits

Flexible work arrangements

Qualifications

• 5-8 years of experience in PK/PD modeling in pharma or biotech.
• Proficiency in modeling software like NONMEM and R.
• Strong understanding of regulatory guidelines.

Responsibilities

• Lead development of PK/PD modeling strategies.
• Perform population pharmacokinetics (PopPK) and exposure-response modeling.
• Collaborate on regulatory submissions and author analysis plans.

Skills

Analytical skills

Project management

Data interpretation

Education

PhD in Pharmaceutical Sciences

PharmD/MSc with modeling experience

Tools

NONMEM

R

MATLAB

Job description

Social network you want to login/join with:

Senior PKPD Modeller, warrington, cheshire

col-narrow-left

Client:

Barrington James

Location:

Job Category:

Other

-

EU work permit required:

Yes

col-narrow-right

Job Views:

3

Posted:

31.05.2025

Expiry Date:

15.07.2025

col-wide

Job Description:

Job Summary:

We are seeking an experienced and driven Senior PK/PD Modeller to join our Clinical Pharmacology team. In this role, you will be responsible for the design, development, and implementation of pharmacokinetic/pharmacodynamic (PK/PD) modeling strategies to support drug development across all phases. You will collaborate cross-functionally with pharmacometrics, clinical, regulatory, and nonclinical teams to provide quantitative insight into drug behavior and inform key decision-making.

Key Responsibilities:

• Lead the development and execution of PK/PD modeling and simulation strategies for preclinical and clinical programs.
• Perform population pharmacokinetics (PopPK), exposure-response (E-R), and physiologically-based pharmacokinetic (PBPK) modeling.
• Translate complex quantitative data into actionable insights for dose selection, trial design, and regulatory interactions.
• Author or contribute to clinical study protocols, pharmacometric analysis plans, and regulatory submissions (IND, NDA, BLA, MAA, etc.).
• Serve as subject matter expert in modeling approaches and mentor junior scientists in PK/PD methodologies.
• Collaborate with biostatistics, clinical pharmacology, regulatory affairs, and other key stakeholders to integrate modeling insights into overall development strategy.
• Maintain awareness of new scientific and regulatory developments in pharmacometrics and contribute to external publications and presentations when appropriate.

Qualifications:

• PhD in Pharmaceutical Sciences, Pharmacology, Applied Mathematics, Biomedical Engineering, or related field; or PharmD/MSc with significant modeling experience.
• Minimum of 5–8 years of hands-on experience in PK/PD modeling, preferably within the pharmaceutical or biotechnology industry.
• Proficiency in NONMEM, Monolix, R, Phoenix WinNonlin, MATLAB, or other relevant software tools.
• Strong understanding of regulatory guidance and expectations related to modeling and simulation (e.g., FDA, EMA).
• Demonstrated ability to interpret and communicate complex data effectively to both technical and non-technical stakeholders.
• Track record of contributions to regulatory filings and/or scientific publications.
• Strong analytical, organizational, and project management skills.

Preferred Skills:

• Experience in mechanistic modeling or QSP (Quantitative Systems Pharmacology).
• Familiarity with PBPK modeling platforms (e.g., Simcyp, GastroPlus).
• Experience in oncology, CNS, immunology, or other specific therapeutic areas is a plus.
• Leadership in cross-functional project teams.

Why Join Us?

You’ll be part of a collaborative and innovative environment where your expertise will directly impact the development of transformative therapies. We offer a competitive salary, comprehensive benefits, flexible work arrangements, and the opportunity to grow professionally in a science-driven organization.