Senior Laboratory Research Scientist (SLRS) - Boulton lab

Second Renaissance; London; On-site; GBP 35,000 - 50,000; Full time

Job summary

A leading biomedical research institute in London is seeking a Senior Laboratory Research Scientist to support innovative research on telomere biology and drug discovery. The role involves collaboration across various fields to validate ALT targets, develop assays, and help shape future cancer therapies in a dynamic environment focused on creativity and collaboration.

Benefits

28 days of annual leave

Generous pension scheme

24/7 GP consultation services

Childcare support allowance

Discounted gym memberships

Qualifications

• Ph.D. or equivalent experience in relevant disciplines.
• Strong track record in target validation supported by publications.
• Practical experience in mammalian cell culture techniques.

Responsibilities

• Validation of ALT targets and characterisation of underlying mechanisms.
• Development of mechanistic assays using ALT markers.
• Screening novel chemical modulators of ALT.

Skills

Cell Culture Techniques

Target Validation

Molecular Biology

Mechanistic Analysis

Education

PhD in Cell or Molecular Biology

Job description

Senior Laboratory Research Scientist (SLRS) - Boulton lab

About us
The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

About the role
This exciting research project is a cross-Francis Crick Institute collaboration focussing on the translation of cutting-edge research led by Dr. Simon Boulton and carried out in the Double Strand Break (DSB) Metabolism Laboratory. Researchers in the DSB Metabolism Laboratory have identified several cellular processes that contribute to the alternative lengthening of telomeres (ALT) mechanism of telomere maintenance present in a sub set cancers (ALT positive cancers). This collaboration aims to translate the new ALT biology insights from the DSB Metabolism Laboratory into therapies to treat ALT positive cancers. This position will give scientists the opportunity to gain experience of drug discovery interfaced with cutting-edge disease biology, with guidance from experienced pharmaceutical research experts and world leaders in the field of DNA Damage Repair.

This work is funded through a 3-year £3M programme of work supported by the philanthropic Chris Banton fund and LifeArc. The project brings together a growing team of scientists working across several laboratories and scientific technology platforms (STPs) at the Francis Crick Institute.

What you will be doing
We are looking for an ambitious and creative cell biologist, ideally with telomere biology experience, to join the ALT programme team at the Francis Crick Institute. You will be an integral part of the ongoing target validation and drug discovery project to identify, characterise and optimise chemical leads for the newly elucidated ALT-dependent cellular processes.

The ALT project is highly multidisciplinary, comprising scientists from a variety of backgrounds in an integrated academia-industry setting.

In collaboration with the ALT project team, you will contribute to the validation and elucidation of detailed molecular mechanism of action of new ALT targets and the development of cell-active chemical tools to translate these findings into more biologically relevant systems. In parallel, you will work with postdoctoral scientists in the Boulton lab and computational chemists, structural biologists and biophysicist to help optimise the chemical tools, designing cellular assay systems to inform on structure activity relationships and drive compound optimisation.

You will be a be a goal-orientated multitasker and an independent thinker, with the ability to initiate and run projects, as well as co-lead collaborative teams, taking advantage of the many training opportunities this work will provide. If you are someone who thrives in dynamic, fast- paced and creative environments, this may be a great opportunity for you to join the lab.

As a Senior Laboratory Research Scientist at the Crick, your key responsibilities will include:

- Validation of ALT targets validation and characterisation of the underlying mechanisms of action, including potential resistance mechanisms.

• Development, optimisation and routine use of cellular mechanistic assays utilising ALT markers such as TIFs, APBs, C-circles, ssTELOC/G and ALT-DNA synthesis to elucidate target engagement.
• Establishing new capability and technology development to enable novel insights into the ALT targets.
• Screening of novel chemical modulators of ALT and characterisation of the mechanisms of action.
• Routine and thorough capture of all assay data in an ELN, such as Dotmatics.
  
  About you
  You will bring
  
  - PhD (or equivalent experience level) in a relevant discipline such as cell and/or molecular biology.
• A strong track record of target validation and mechanistic analysis using innovative cellular assays in academic or industrial research, ideally supported by publications in peer-reviewed journals.
• Practical experience of mammalian cell culture techniques for the development of cellular assays, ideally with an understanding of genome/telomere maintenance processes.
• Knowledge and/or practical experience of cell and molecular biology.
  
  About Working at the Crick
  Our values
  Everyone who works at the Crick has a valuable role to play in advancing the Crick’s mission and shaping our culture!
  
  - We arebold. We make space for creative, dynamic and imaginative ideas and approaches. We’re not afraid to do things differently.
  
  - We areopen. We’re highly collaborative and interactive, and make sure our activities are visible to the outside world.
  
  - We arecollegial. We show respect for one another, work cooperatively and support the wider community.
  
  At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. Weare aDisability Confident: Committedemployer andwant to ensure that everyone can apply and be part of our recruitment processes and sowe'llmake reasonable adjustments if you need them - just let us know when you apply. If you needassistancewith applying (i.e., would like to apply by phone or post)please email: [e-mail]
  
  To find out more about life at the Crick click here.
  
  What will you receive?
  At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development:
  
  - Visas: Applicants for this role will be eligible for sponsorship to work in the UK
  
  - Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays.
  
  - Pension Scheme: Defined contribution pension with employer contributions of up to 16%.
  
  - Health & Well-being:
  
  - 24/7 GP consultation services.
  
  - Occupational health services and mental health support programs.
  
  - Eye care vouchers and discounted healthcare plans.
  
  - Work-Life Balance:
  
  - Back-up care for dependents.
  
  - Childcare support allowance.
  
  - Annual leave purchase options.
• Crick Networks offering diverse groups’ support, community and inclusive social events.
  
  - Perks:
  
  - Discounted gym memberships, bike-to-work scheme, and shopping discounts.
  
  - Subsidised on-site restaurant and social spaces for team interaction.
  
  - Development & Recognition: Comprehensive training, mentoring, and a pay structure with performance-linked progression.