Senior Laboratory Research Scientist

LLOYD'S REGISTER INTERNATIONAL; Crick; On-site; GBP 42,000 - 52,000; Full time

Job summary

Francis Crick Institute is seeking a Senior Laboratory Research Scientist to lead advanced organoid projects within the SCOP. You will develop complex 3D human models, including patient-derived and iPSC-derived organoids, and support cross-Crick collaborations.

You will train researchers, contribute to SOPs, and ensure high-quality, reproducible science while maintaining day-to-day stem cell operations in a collaborative environment.

Qualifications

• Higher degree in a relevant field (PhD or MSc) with research experience in stem cell biology or organoid technologies.
• Extensive proficiency in developing, maintaining and troubleshooting complex organoid systems, including patient-derived organoids, iPSC-derived organoids, co-culture systems, spheroids, assembloids.
• Strong background in stem cell biology with hands-on culture of human pluripotent stem cells.
• Experience processing primary tissue samples such as tissue biopsies and blood.
• Strong knowledge of immunohistochemistry, immunofluorescence and imaging.
• Excellent attention to detail and collaborative working skills.
• Experience mentoring or supporting researchers.

Responsibilities

• Leading organoid and stem cell projects across research and service activities within SCOP.
• Developing and optimising advanced 3D human models, including patient-derived and iPSC-derived organoids.
• Supporting quality control, troubleshooting and reproducibility of organoid workflows.
• Collaborating with research groups and other Science Technology Platforms across the Crick.
• Providing training, mentorship and technical guidance in organoid and stem cell techniques.
• Developing SOPs, project documentation and best-practice workflows.
• Supporting day-to-day laboratory operations and stem cell maintenance activities.

Skills

Stem cell biology

Organoid technologies

iPSC-derived models

Immunohistochemistry

Immunofluorescence

3D organoid culture

Mentoring

Education

PhD or MSc in a relevant field

Tools

Genome editing workflows

Automation tools familiarity

Organ-on-a-chip concepts

Job description

Senior Laboratory Research Scientist

In the Crick's Stp |Stem Cells And Organoids Platform.

Key information

Senior Laboratory Research Scientist – Organoids

Contract term: This is a full-time permanent position on Crick terms and conditions of employment.

Reporting to: Sara Tamagno, SCOP Lead

Salary for this Role: From £47,080 with benefits, subject to skills and experience

About us

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

About the Stem Cells and Organoid Platform (SCOP)

The Stem Cells and Organoids Platform (SCOP) at the Francis Crick Institute is a Science Technology Platform (STP) dedicated to advancing innovative research in human stem cell biology and organoid technologies. It provides specialised expertise and services that support the development of human model systems. By integrating complementary expertise in stem cells, gene editing, and organoid development, the platform provides an end-to-end pipeline for stem cell research, accelerating cutting-edge discovery across the institute.

About the role

We are seeking a highly motivated Senior Laboratory Research Scientist to lead and support advanced organoid and 3D human model projects within SCOP.

Working at the forefront of human in vitro model technologies, you will develop and optimize complex organoid systems including patient-derived and iPSC-derived models, while supporting collaborative research projects across the Crick. You will also play a key role in establishing new shared workflows, training researchers and helping shape the Crick’s capabilities in organoid technologies and stem cell biology.

What you’ll be doing

You will be responsible for:

• Leading organoid and stem cell projects across research and service activities within SCOP.
• Developing and optimising advanced 3D human models, including patient-derived and iPSC-derived organoids.
• Supporting quality control, troubleshooting and reproducibility of organoid workflows.
• Collaborating with research groups and other Science Technology Platforms across the Crick.
• Providing training, mentorship and technical guidance in organoid and stem cell techniques.
• Developing SOPs, project documentation and best-practice workflows.
• Supporting day-to-day laboratory operations and stem cell maintenance activities.

About you

You will have:

Essential:

(Minimum criteria*)

• Higher degree in a relevant field (PhD or MSc) with research experience in stem cell biology or organoid technologies.*
• Extensive proficiency in developing, maintaining and troubleshooting complex organoid systems, including patient-derived organoids, iPSC-derived organoids, co-culture systems, spheroids, assembloids, or other advanced 3D human model*
• Strong background in stem cell biology, with hands-on experience in the culture and maintenance of human pluripotent stem cells (iPSCs and/or ESCs).*
• Experience processing primary tissue samples, such as tissue biopsies and blood.*
• Strong scientific knowledge of techniques such as immunohistochemistry, immunofluorescence, and imaging*
• Strong organisational, communication and collaborative working skills.
• Experience mentoring or supporting researchers within a laboratory environment.
• Excellent attention to detail and commitment to high-quality, reproducible science.

Desirable

• Experience with genome editing or genetic modification workflows.
• Familiarity with automation tools, organ-on-a-chip systems or microfluidics.
• Experience with bioreactors or large-scale cell culture systems.
• Experience working within a user-facing platform or shared research facility.

About Working at the Crick

Our values

Everyone who works at the Crick has a valuable role to play in advancing the Crick’s mission and shaping our culture!

• We arebold. We make space for creative, dynamic and imaginative ideas and approaches. We’re not afraid to do things differently.

• We areopen. We’re highly collaborative and interactive, and make sure our activities are visible to the outside world.

• We arecollegial. We show respect for one another, work cooperatively and support the wider community.

At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. Weare aDisability Confident: Committedemployer andwant to ensure that everyone can apply and be part of our recruitment processes and sowe'llmake reasonable adjustments if you need them - just let us know when you apply. If you needassistancewith applying (i.e., would like to apply by phone or post)please email: [e-mail].

What will you receive?

At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development:

• Visas:Applicants for this role will be eligible for sponsorship to work in the UK

• Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays.

• Pension Scheme: Defined contribution pension with employer contributions of up to 16%.

• Health & Well-being:

• 24/7 GP consultation services.

• Occupational health services and mental health support programs.

• Eye care vouchers and discounted healthcare plans.

• Work-Life Balance:

• Back-up care for dependents.

• Childcare support allowance.

• Annual leave purchase options.
• Crick Networks offering diverse groups’ support, community and inclusive social events.

• Perks:

• Discounted gym memberships, bike-to-work scheme, and shopping discounts.

• Subsidised on-site restaurant and social spaces for team interaction.

• Career support: Since September 2017 Crick has been a signatory to the Technician Commitment, an initiative across the research sector to ensure visibility, recognition, career development and sustainability for technicians working in higher education and research, across all disciplines.

Please note you must meet the essential criteria listed within the Role Profile, to have your application reviewed.