Scientist - Separation Sciences

Merck Gruppe - MSD Sharp & Dohme; London; On-site; GBP 35,000 - 50,000; Full time

Job summary

A leading company in drug discovery is seeking a Scientist to join their Separations team in London. This role involves conducting analytical processes, maintaining chromatographic equipment, and contributing to method development in a collaborative research environment. Ideal candidates will possess a degree in Chemistry or related field, complemented by analytical hands-on experience.

Qualifications

• Strong understanding of analytical and separation chemistry concepts.
• Hands-on experience with LCMS in an analytical lab.
• Ability to perform accurate work with high attention to detail.

Responsibilities

• Act as a super-user of LCMS/HPLC on analytical and preparative scale.
• Maintain and troubleshoot chromatographic instruments.
• Support chemists with analytical method optimization.

Skills

Adaptability

Detail-Oriented

Analytical Testing

Communication

Education

BSc or MSc in Chemistry, Biochemistry, or other physical science

Tools

LCMS

HPLC

Job description

Job Description

Our company has grown an interdisciplinary team of scientists in London and has exciting plans to evolve further from our recent expansion into ‘Skylab’ at the Francis Crick Institute to the move into our new ‘state of the art’ London Discovery Research Centre and UK headquarters at the heart of London’s Knowledge Quarter in 2027. This will be home to approximately 180 scientists alongside other colleagues in clinical, regulatory, and business roles, including marketing, finance, and administration.

Our teams combine leading drug discovery capabilities and world-class R&D with the purpose of turning breakthrough science into life-changing medicines, applyingleading-edge chemistryto support target validation and identify high quality clinical candidates.

We are currently recruiting a Scientist to join a growing Separations team in a laboratory-based role. The successful candidate will actively participate in a vibrant culture as part of a diverse and collaborative multidisciplinary team. The candidate must have strong organisation skills, be highly self-motivated and have excellent written and oral communication abilities.

Primary responsibilities include:

• Acting as a super-user of LCMS/HPLC Open Access capabilities on both an analytical and preparative scale
• Maintaining and troubleshooting various chromatographic instrumentation
• Supporting medicinal chemists with analytical and purification method optimisation

In addition, the candidate will share and apply the best practices to enable continuous chromatography improvement. This will involve driving the execution of compound purification and method development.

To accomplish the above the successful candidate must demonstrate strong interpersonal communication, flexibility, time management and a keen initiative to support project needs. This will involve liaising with multiple departments across the network.

Education Minimum Requirement:

• The candidate will possess a BSc or MSc in Chemistry, Biochemistry, or other physical science

Required Experience:

• Understanding of analytical and separation chemistry concepts, including Reverse-Phase chromatography
• Hands-on experience using LCMS (Liquid Chromatography Mass Spectroscopy) in an analytical/purification lab
• The ability to perform accurate and timely work
• High self-motivation, a collaborative mindset and an attention to detail. A keen willingness to learn to support cross-functional teams across growing research programs

Preferred Experience and Skills:

• Setup and ability to troubleshoot analytical and preparative HPLC instrumentation
• Knowledge of HPLC and/or SFC purification of small molecules
• Experience in method development using achiral and/or chiral techniques
• Ability to multi-task and deliver on multiple priorities simultaneously
• Experience of high-throughput automation and instrumentation

Closing date for applications: 22nd July 2025

Current Employees apply HERE

Current Contingent Workers apply HERE

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

VISA Sponsorship:

Travel Requirements:

Flexible Work Arrangements:

Not Applicable

Shift:

Valid Driving License:

Hazardous Material(s):

Required Skills:

Adaptability, Analytical Instrumentation, Analytical Method Development, Analytical Problem Solving, Analytical Testing, Antibody Drug Conjugates (ADC), Business, Chemistry Techniques, Communication, Detail-Oriented, Laboratory Safety, Liquid Chromatography-Mass Spectrometry (LC-MS), Organic Synthesis, Preparative Chromatography, Purification Methods, Reverse Phase Chromatography, Science, Social Collaboration

Preferred Skills:

Job Posting End Date:

07/23/2025

*A job posting is effective until 11:59:59PM on the day BEFOREthe listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID:R356819