Scientist in Translational Pathology, Oncology

AstraZeneca; Cambridge; On-site; GBP 35,000 - 55,000; Full time

Job summary

A leading company in oncology is seeking a Scientist in Translational Pathology to enhance its R&D efforts. The role involves advanced biomarker analysis in a dynamic GCP environment. Candidates should have relevant education and experience in immunohistochemistry and microtomy and engage collaboratively to improve cancer treatment outcomes.

Qualifications

• Experience in manual or automated immunohistochemistry (brightfield or fluorescence).
• Experience working to Good Clinical Practice.
• Knowledge in AZ portfolio areas: tumor drivers, DNA damage response, immuno-oncology.

Responsibilities

• Utilize cutting-edge science for routine biomarker analysis.
• Interpret and communicate data to influence clinical decisions.
• Study tumors to uncover novel resistance mechanisms.

Skills

Immunohistochemistry

Microtomy

Human tissues handling

Sample tracking

Education

BSc or Master’s in a relevant field

Job description

Job Title: Scientist in Translational Pathology, Oncology

Introduction to role:

Are you ready to be at the forefront of translational science in oncology? Join AstraZeneca's Translational Pathology group within the Oncology R&D Translational Medicine department and make a significant impact on our industry-leading portfolio! Dive into early clinical development and post-marketing opportunities that support targeted therapies, all while collaborating across global boundaries to tackle challenges with integrity.

Accountabilities:

In this dynamic role, you'll work in a Good Clinical Practice (GCP) environment, utilizing cutting-edge science and technology for routine biomarker analysis. You'll interpret and communicate data as part of a matrix team, influencing clinical decisions on therapeutically relevant doses and schedules. Your work will deepen our understanding of cancer pathway interactions, guide rational drug combinations, and uncover novel resistance mechanisms by studying tumors at relapse.

Essential Skills/Experience:

• BSc or Master’s in a relevant field

• Experience in manual or automated immunohistochemistry (brightfield or fluorescence)

• Experience in microtomy

• Experience working to Good Clinical Practice

• Experience working with human tissues and tissue-based histopathology methods

• Knowledge or experience in one or more AZ portfolio areas: tumor drivers and resistance, DNA damage response (DDR), immuno-oncology (IO), and antibody drug conjugates (ADC)

• Experience of tracking and/or managing human tissues using sample tracking software (e.g., BSI, SAPIO, Azenta etc.)

Desirable Skills/Experience:

• Skilled in development and validation of biomarker assays

• Experience with digital image analysis solutions (e.g., ImageJ, HALO, Visiopharm etc.)

• Skills in developing multiplexed immunohistochemistry or in situ hybridization (ISH) assays

• Career exposure to the pharmaceutical industry and the drug development process

AstraZeneca is a place where courage, curiosity, and collaboration thrive. We are driven by patient outcomes and empowered to lead at every level. With an ambitious goal to deliver 6 new molecular entities by 2025, we fuse cutting-edge science with the latest technology to achieve breakthroughs. Our collaborative research has built an unrivaled scientific community, uniting academia and industry to expedite research in hard-to-treat cancers. Join us and be part of a team committed to improving the lives of millions with cancer.

Ready to pioneer new frontiers in oncology? Apply now and be part of our journey!

Date Posted

02-jun.-2025

Closing Date

15-jun.-2025 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.