Scientist III: RNA

JR United Kingdom; Cambridge; On-site; GBP 30,000 - 60,000; Full time

Job description

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4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA and RNA for use in gene therapy, vaccines and gene editing platforms including RNA based therapeutics. We are expanding our R&D teams at our site in Cambridge, UK to facilitate the scaling of our proprietary DNA manufacturing process including RNA synthesis and development of nanoparticle vectors for nucleic acid delivery. We are looking for dynamic and experienced team members to help us achieve our ambitions and goals.

Job purpose:

To contribute to new client or collaborator on RNA synthesis and related R&D projects. Contribute to development of novel RNA based products offering solutions in therapeutic and applied space.

Responsibilities:

1. Work as part of the RNA team, to be able of generating consistent and valuable data for collaborative and client based projects
2. Perform screening and optimisation experiments using 4basebio DNA for in vitro transcription (IVT) for various applications (mRNA, saRNA and circRNA)
3. Perform RNA purification and analytics on mRNA and saRNA produced with IVT
4. Nanopore based direct RNA sequencing of IVT products and its analysis
5. Execute and deliver projects to a high standard and in accordance with project plans
6. Analyse and interpret experimental data; identify and solve experimental problems
7. Work collaboratively and support the R&D functions of the company
8. Record experimental methods and results to a high standard and in-line with company guidelines
9. Attend and participate in relevant meetings, training, and development sessions
10. Keep up to date with relevant scientific and technical developments
11. Undertake any other appropriate roles and responsibilities that reasonably fall within the role holder’s skills and experience as requested
12. Use and maintain company equipment in accordance with the company’s SOPs and health & safety guidelines

Person Specification:

1. MSc with relevant experience or PhD in biological sciences, molecular biology, or in life sciences
2. Hands-on experience working in molecular biology preferably RNA related projects in R&D labs
3. Knowledge and practical experience in molecular biology with focus on RNA based techniques
4. Experience in analytical techniques including agarose and polyacrylamide gel electrophoresis, nanopore RNA sequencing, capillary electrophoresis, ELISA, qPCR, flow cytometry, dot blot
5. Ability to test and troubleshoot new assays and techniques
6. Excellent team working and communication skills
7. Must hold the Right to Work in the UK

What we offer:

Competitive salary + comprehensive benefits package

Location:

This role is located in Over, North of Cambridge

We are unable to offer sponsorship for this role.

Due to the high number of applicants, if you do not hear back from us within six weeks, we thank you for your interest, but please assume you have not been selected for interview on this occasion.