Scientist III: RNA

ZipRecruiter; Cambridge; On-site; GBP 35,000 - 55,000; Full time

Job summary

An innovative gene synthesis company is seeking dynamic team members to join their R&D teams in Cambridge. This role focuses on RNA synthesis and the development of novel RNA-based products for therapeutic applications. You'll work collaboratively to generate consistent data, perform critical experiments, and contribute to groundbreaking projects. The company offers a competitive salary and a comprehensive benefits package, creating an exciting environment for those passionate about molecular biology and RNA technologies.

Benefits

Comprehensive Benefits Package

Competitive Salary

Qualifications

• MSc or PhD in relevant biological sciences with hands-on R&D experience.
• Practical knowledge in RNA techniques and molecular biology.

Responsibilities

• Generate valuable data for collaborative RNA projects.
• Perform RNA purification and analytics on IVT products.
• Execute projects to high standards and analyze experimental data.

Skills

Molecular Biology

RNA Techniques

Analytical Techniques

Teamwork

Communication Skills

Education

MSc in Biological Sciences

PhD in Molecular Biology

Tools

Agarose Gel Electrophoresis

Polyacrylamide Gel Electrophoresis

Nanopore RNA Sequencing

Capillary Electrophoresis

ELISA

qPCR

Flow Cytometry

Dot Blot

Job description

Job Description

4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA and RNA for use in gene therapy, vaccines and gene editing platforms including RNA based therapeutics. We are expanding our R&D teams at our site in Cambridge, UK to facilitate the scaling of our proprietary DNA manufacturing process including RNA synthesis and development of nanoparticle vectors for nucleic acid delivery. We are looking for dynamic and experienced team members to help us achieve our ambitions and goals.

Job purpose:

To contribute to new client or collaborator on RNA synthesis and related R&D projects. Contribute to development of novel RNA based products offering solutions in therapeutic and applied space.

Responsibilities:

• Work as part of the RNA team, to be able of generating consistent and valuable data for collaborative and client based projects
• Perform screening and optimisation experiments using 4basebio DNA for in vitro transcription (IVT) for various applications (mRNA, saRNA and circRNA)
• Perform RNA purification and analytics on mRNA and saRNA produced with IVT
• Nanopore based direct RNA sequencing of IVT products and its analysis
• Execute and deliver projects to a high standard and in accordance with project plans
• Analyse and interpret experimental data; identify and solve experimental problems
• Work collaboratively and support the R&D functions of the company
• Record experimental methods and results to a high standard and in-line with company guidelines
• Attend and participate in relevant meetings, training, and development sessions
• Keep up to date with relevant scientific and technical developments
• Undertake any other appropriate roles and responsibilities that reasonably fall within the role holder’s skills and experience as requested
• Use and maintain company equipment in accordance with the company’s SOPs and health & safety guidelines

Person Specification:

• MSc with relevant experience or PhD in biological sciences, molecular biology, or in life sciences
• Hands-on experience working in molecular biology preferably RNA related projects in R&D labs
• Knowledge and practical experience in molecular biology with focus on RNA based techniques
• Experience in analytical techniques including agarose and polyacrylamide gel electrophoresis, nanopore RNA sequencing, capillary electrophoresis, ELISA, qPCR, flow cytometry, dot blot
• Excellent record keeping skills
• Ability to test and troubleshoot new assays and techniques
• Excellent team working and communication skills
• Must hold the Right to Work in the UK

What we offer:

Competitive salary + comprehensive benefits package

Location:

This role is located in Over, North of Cambridge

We are unable to offer sponsorship for this role.

Due to the high number of applicants, if you do not hear back from us within six weeks, we thank you for your interest, but please assume you have not been selected for interview on this occasion.