Scientist II, Molecular Biology & Gene Editing

ZipRecruiter; Cambridge; On-site; GBP 40,000 - 80,000; Full time

Job description

Job Description

At Editas Medicine, we are pioneering the possible. Our mission and commitment is to translate the power and potential of the CRISPR/Cas12a and CRISPR/Cas9 genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for a broad class of diseases.

Why Choose Editas?

At Editas Medicine, we’re a team of passionate problem solvers, harnessing the power and potential of CRISPR gene editing to transform the future of medicine. Driven by a shared purpose to serve people living with serious diseases, we succeed together through collaboration, mutual respect, and innovation. If you want to be part of a team where your voice is heard and respected, where you can operate at the forefront of gene editing, and push the boundaries of what’s possible in medicine, come join us and become an Editor!

Decoding The Role:

Editas Medicine is seeking an accomplished Scientist to join our Molecular Biology & Gene Editing group. This individual will support the design and execution of novel engineered gene editing technologies by leveraging their expertise in molecular biology techniques, such as plasmid design and various molecular cloning techniques. The Scientist will play a key role in evolving the current and next generation of gene editing platforms at Editas.

Characterizing Your Impact:

As the Scientist II, Molecular Biology & Gene Editing, you will:

• Be part of a dedicated team to develop innovative gene editing platform technologies.
• Design and execute directed evolution and/or rational design processes to engineer gene editing technologies with desired properties, including precision genomic editing technologies.
• Design and construct libraries using rational and combinational molecular biology methods.
• Develop in vitro or cell-based high throughput screening methods for functional readout.
• Build assays to quantify and measure efficacy and specificity of novel gene editing technologies in vivo and in vitro.
• Provide training, scientific and personnel management for junior team members.

Requirements

The Ideal Transcript:

To thrive in this role, you’ll need:

Qualifications

• Ph.D. in cell biology, molecular biology, bioengineering, or a related field
• 2+ years of industry experience in molecular biology or a related field
• Molecular and cell biology expertise including plasmid design and library preparation, molecular cloning techniques such as Gibson assembly and golden gate cloning, primer design, PCR, gel electrophoresis, DNA and RNA purification, in vitro transcription, LNP formulation, qPCR/RT-qPCR, ddPCR/RT-ddPCR, and flow cytometry.
• Extensive experience in mammalian cell culture, transfections, and cell-based assays
• Experience working with CRISPR and non-viral (LNP) and/or viral (AAV, lentivirus) delivery vectors
• Familiarity with DNA analysis software such as VectorNTI, Geneious, Benchling

Fundamentals That Set You Apart

• Preferably knowledge in genetic diseases, precision gene editing, and gene therapy.
• Experience in protein structure-function study, protein engineering, and directed evolution.
• An ability to work in a fast-paced, team-oriented, multidisciplinary environment.

Benefits

Benefits Summary:

Editas provides a comprehensive array of benefits to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings Account, Dental and Vision Insurance, Life and Insurance, Dependent Care Account, Tuition Reimbursement, 401(k) plan with company match, Employee Stock Purchase Plan, Employee Assistance Plan, Wellness Programs, and a flexible Paid Time Off policy.

Aspire to be an Editor? We invite you to apply and join us at the forefront of innovation and be a key contributor to realizing Editas Medicine's mission of developing transformative medicines for people living with serious diseases.