Scientist II: Analytical Development

JR United Kingdom; Manchester; On-site; GBP 30,000 - 45,000; Full time

Job summary

A leading company in gene synthesis is seeking a Scientist II for Analytical Development in Manchester. The role involves developing new analytical methods for synthetic DNA products and collaborating with R&D. Ideal candidates should have a strong background in biochemistry and proven analytical skills, offering a competitive salary, healthcare, and other benefits.

Benefits

Competitive salary

Private healthcare

Pension contributions

Life assurance

Qualifications

• MSc or BSc in science field with 2+ years relevant experience.
• Hands-on experience in biological or chemical labs.
• Proficiency in analytical techniques for nucleic acids and proteins.

Responsibilities

• Design and validate analytical assays for biomolecules.
• Develop analytical methods including HPLC and CGE.
• Collaborate with R&D for new analytical methods.

Skills

Analytical techniques

Enzyme characterization

Molecular characterization

Laboratory skills

Troubleshooting assays

Teamwork

Communication

Education

MSc in biochemistry, chemistry, or related life science

BSc in biological/chemical sciences

Tools

Nanodrop

Qubit

SDS-PAGE

ELISA

HPLC

Western blotting

Job description

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Scientist II: Analytical Development, manchester

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Client:

4basebio

Location:

manchester, United Kingdom

Job Category:

Other

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EU work permit required:

Yes

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Job Views:

1

Posted:

04.06.2025

Expiry Date:

19.07.2025

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Job Description:

4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapy and gene editing platforms. We are starting our DNA analytic facilities at our site in Cambridge, UK and are looking for dynamic and experienced team members to help us achieve our ambitions and goals.

The role will focus on the development of new methods for the analysis of our novel, synthetic DNA products for customer and discovery projects. It will be also focus on the development of analytical tools to characterize enzymes and other biomolecules that works as raw materials for DNA synthesis. The candidate will have opportunity to interact with multi-disciplinary teams within the R&D department and expand their laboratory skill set.

Key Responsibilities:

• Design, develop, and validate analytical assays for enzyme characterization, DNA, RNA, and other biomolecules.
• Implement assays such as PCR, qPCR, ELISA, and gel electrophoresis to assess enzyme activity and molecular integrity essential.
• Develop analytical methods and carry out laboratory analysis using a range of techniques including CGE and HPLC.
• Work in collaboration with R&D for the development of new analytical methods for nucleic acids and proteins.
• Ensure assays meet regulatory standards and are suitable for QC testing and product release.
• Analyse and interpret experimental data; identify and solve experimental problems.
• Use and maintain company equipment in accordance with the company’s SOPs and health & safety guidelines.
• Keep up to date with relevant scientific and technical developments.
• Establish and maintain a detailed record of all the experiments and results generated in the lab.

Person Specification:

• MSc in biochemistry, chemistry, or related life science field or BSc in biological/chemical sciences, or a related discipline with relevant industry experience (2+ Years).
• Hands-on experience working in biology or chemistry labs.
• Experience in analytical techniques for nucleic acids characterization and quantification: Nanodrop, Qubit, AGE, CGE, sequencing.
• Experience in analytical techniques for proteins characterization and quantification: SDS-PAGE gels, silver staining, western blotting, plate-based assays (ELISA, enzymes activity assays, BCA)
• Experience in tech transfer documentation generation.
• Ability to test and troubleshoot new assays and techniques.
• Excellent team working and communication skills.
• Must have the right to work in the UK

What we can offer: Competitive salary + private healthcare + pension contributions + life assurance

Due to the high number of applicants, if you do not hear back from us within 6 weeks, we thank you for your interest, but please assume you have not been selected for interview on this occasion.