Scientist, DNA Extraction and Library Prep - Pathogen

The Ellison Institute of Technology (EIT) Oxford tackles humanity's greatest challenges by turning science and technology into impactful global solutions. Focused on areas like health, food security, sustainable agriculture, climate change, clean energy, and AI-driven government innovation, EIT Oxford blends groundbreaking research with practical applications to deliver lasting results.

A cornerstone of EIT Oxford's mission is its upcoming 300,000-square-foot research facility at the Oxford Science Park, set to open in 2027. This cutting-edge campus will feature advanced labs, an oncology and preventative care clinic, and collaborative spaces to strengthen its partnership with the University of Oxford. It will also host the Ellison Scholars, driving innovation for societal benefit.

The Pathogen Mission highlights EIT's transformative approach, using Whole Genome Sequencing (WGS) and Oracle's cloud technology to create a global pathogen metagenomics system. This initiative aims to improve diagnostics, provide early epidemic warnings, and guide treatments by profiling antimicrobial resistance. The goal is to deliver certified diagnostic tools for widespread use in labs, hospitals, and public health.

EIT Oxford fosters a culture of collaboration, innovation, and resilience, valuing diverse expertise to drive sustainable solutions to humanity's enduring challenges.

We are seeking a Scientist, DNA Extraction and Library Preparation to support the research and product development of EIT Oxford's Pathogen Programme. The lab-based role involves designing methods for extracting and manipulating DNA and other relevant biological substances from microbial pathogens (bacteria, viruses, fungi and other eukaryotes) from clinical and other sources to inform the diagnosis and treatment of infectious disease in humans. The role will involve working with other scientists and engineers in small teams to deliver the project milestones.

Key Responsibilities:

• Design experiment, tests, and protocols to optimise the quality and quantity of DNA extracted from a range of biological samples
• Prepare libraries from extracted DNA, sequencing using Oxford Nanopore's MinION, analyse sequencing results and feedback information to optimise extraction and library preparation
• Work in partnership with the teams developing the fluidics and instrumentation to ensure that appropriate methods are transferred to the automated platform while maintaining performance

Qualifications & Experience:

• PhD or equivalent experience in Biology, Biochemistry, Chemistry, or related field with specialisation in DNA handling and manipulation
• Hands-on experience of extracting DNA or RNA, sequencing, and data analysis
• Proficiency in molecular biology techniques: qPCR, RT-PCR, gel electrophoresis, spectrophotometry, fluorometry and familiarity with DNA/RNA quantification and quality control (e.g., Nanodrop, Qubit, Bioanalyzer)
• Experience of library preparation and sequencing with Oxford Nanopore products

Desirable Knowledge, Skills and Experience:

• Knowledge of non-traditional extraction methods (e.g., PEG-free, ethanol-free, enzymatic, microfluidic-based)
• Experience working with low-input or degraded samples
• Proven ability to design and execute experiments to characterise polynucleotides, enzymes and other proteins
• Expertise in nucleic acid extraction from various biosamples (e.g. blood, saliva, tissue, stool, environmental samples)
• Proficiency in molecular biology techniques: qPCR, RT-PCR, gel electrophoresis, spectrophotometry, fluorometry
• Familiarity with biosafety and sterile technique for working with human or environmental samples
• Track record of innovation (e.g., patents, publications, or commercial products)

Benefits:

• Salary: Competitive salary on offer
• Enhanced holiday pay
• Pension
• Life Assurance
• Income Protection
• Private Medical Insurance
• Hospital Cash Plan
• Therapy Services
• Perk Box
• Electrical Car Scheme

Why work for EIT:

At the Ellison Institute, we believe a collaborative, inclusive team is key to our success. We are building a supportive environment where creative risks are encouraged, and everyone feels heard. Valuing emotional intelligence, empathy, respect, and resilience, we encourage people to be curious and to have a shared commitment to excellence. Join us and make an impact!

Terms of Appointment:

You must have the right to work permanently in the UK with a willingness to travel as necessary.

You will live in, or within easy commuting distance of, Oxford.

During peak periods, some longer hours may be required and some working across multiple time zones due to the global nature of the programme.