Research Technician - UCL

British Neuroscience Association (BNA); Bristol; On-site; GBP 35,000 - 42,000; Full time

Job summary

A leading association focused on neuroscience is seeking a Research Technician to join their team. The role involves analyzing human brain tissues, handling advanced assays, and contributing to significant research concerning neurodegenerative diseases. Applicants should hold a relevant Honours degree and have experience with cellular models and biochemical techniques, supported by enthusiastic involvement in high-quality research.

Qualifications

• Experience with iPSC culture and neuronal differentiation required.
• Knowledge in biochemical analysis and synucleinopathies essential.
• Understanding of the mission of the UK DRI and its research work is necessary.

Responsibilities

• Analyze human post-mortem brain tissue and various cell culture models.
• Employ in vitro aggregation assays and biochemical analyses.
• Support histopathology techniques and protein expression.

Skills

Cell Culture

Biochemical Analysis

Histopathology

Neurodegeneration

Western Blot

Education

Honours degree (minimum 2:1) in Biophysics, Biochemistry, Molecular Biology or a related discipline

Job description

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Vacancy Reference Number B02-08839 Closing Date 1 Jul 2025 Salary £35,930-£41,255 per annum Address UK DRI at UCL, Queen Square- On site Duration The post is available from 01 September 2025 and is funded by the UK DRI for one year in the first instance.

The UK Dementia Research Institute (UK DRI) is the biggest UK initiative supporting research to fill the major knowledge gap in our basic understanding of the diseases that cause dementia.

Research from UK DRI at UCL covers the journey from the patient to the laboratory and back to the patient with improved diagnosis, biomarkers and candidate therapies put to the test.

Based within the UK DRI at UCL, the Bartels Lab specializes in the study of synuclein multimers and lipidomics in the context of Parkinson’s disease (PD). The lab plays a unique role in this field, addressing key research gaps through close collaborations with the National Hospital for Neurology and Neurosurgery and the Queen Square Brain Bank.

Dr Tim Bartels first discovered disease resistant forms of the α-synuclein protein and their destabilization in Parkinson’s Disease. His lab is interested in identifying the different factors that destabilize α-synuclein and that lead to neurotoxicity.

About The Role

We are seeking a Research Technician to contribute to a project involving the analysis of human post-mortem brain tissue and various cell culture models, including iPSC-derived and primary human neurons, as well as structural in vitro assays using recombinant protein. Both native brain tissue and in vitro models will be used to study α-synuclein fibrils across different synucleinopathies.

In vitro aggregation assays, electron microscopy, circular dichroism (CD) spectroscopy, and fluorescence correlation spectroscopy (FCS) will be employed to elucidate context-dependent protein folding. You will provide support with histopathology techniques, biochemical analyses such as crosslinking and Western blotting, cell culture, and protein expression and purification.

About You

You will have an Honours degree (minimum 2:1) or equivalent in Biophysics, Biochemistry, Molecular Biology or a related discipline, and experience with iPSC culture and neuronal differentiation.

A background and knowledge in one or more of the following is essential: Neurodegeneration, synucleinopathies, biochemical analysis, such as detergent extraction and Western Blot, cell culture experience, IHC.

Experience of working with Biophysics, Biochemistry, Molecular Biology, Histology assays is also a requirement, as is an understanding of the mission of the UK DRI, an interest in its research work and a commitment to supporting high quality research.

How to apply: https://www.ucl.ac.uk/work-at-ucl/search-ucl-jobs/details?nPostingId=14363&nPostingTargetId=35222&id=Q1KFK026203F3VBQBLO8M8M07&LG=UK&languageSelect=UK&mask=ext

Contact Details

Informal enquiries regarding the role can be addressed to Dr Tim Bartels [e-mail]

Seniority level

• Seniority level

  Entry level

Employment type

• Employment type

  Full-time

Job function

• Job function

  Research, Analyst, and Information Technology

• Industries

  Non-profit Organizations

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