Research Technician II Formulation

GENERAL SUMMARY / OVERVIEW:
The Gene and Cell Therapy Institute (GCTI) is a newly established system-wide Institute under Mass General Brigham, dedicated to fostering a world-class gene and cell therapy program. The Institute aims to leverage ongoing, groundbreaking scientific research across the MGB system to bring together investigators utilizing gene and cell therapy platforms, with the goal of improving patient health. GCTI will distinguish itself by harnessing the strengths of clinician scientists, the large patient population, and major discoveries within the hospital system to position MGB as a leader in Gene & Cell therapies.

We are seeking a motivated and skilled Technician to join our RNA Therapeutics Core (RTC) team. The successful candidate will participate in developing novel RNA-based medicines and technologies. Under guidance from senior scientific staff, the technician will produce and analyze high-quality lipid nanoparticle formulations of RNA for experimental and external applications, and administer formulated RNA to mice via various injection routes.

The ideal candidate will have experience working in a research laboratory environment, proficiency in standard mouse handling techniques (tail vein injections, subcutaneous injections, sample collection), and lipid nanoparticle formulation. Preferably, they will have hands-on experience in LNP process development, be detail-oriented and organized, and eager to work collaboratively.

MINIMUM QUALIFICATIONS:

• Bachelor's degree in life sciences, biochemistry, chemistry, or chemical engineering with 1-2 years of laboratory experience
• Strong organizational skills and attention to detail
• Reproducibility and accuracy in work
• Computer literacy
• Ability to systematically record data
• Effective interpersonal and communication skills
• Professionalism and dedication to excellence

PREFERRED COMPETENCIES:

• Experience working with mice
• Experience formulating and analyzing lipid nanoparticles

PRINCIPAL DUTIES AND RESPONSIBILITIES:

• Perform routine procedures such as lipid nanoparticle formulation, flash freezing, and dialysis following established methodologies
• Conduct analytical techniques including dynamic light scattering and nucleic acid entrapment assays, ensuring accuracy and reproducibility
• Handle mice for procedures like tail vein injections, anesthesia, bleeds, live imaging, and wellness monitoring
• Operate laboratory equipment and learn to use new instruments and robotics
• Follow safety protocols and use personal protective equipment to handle biohazardous materials; complete required trainings
• Participate in lab meetings and suggest improvements for efficiency and productivity
• Communicate effectively with team members, discuss progress, and share data with supervisors
• Perform other duties as assigned

This position is onsite at 65 Landsdowne Street, Cambridge, MA.

Mass General Brigham Inc. is an Equal Opportunity Employer committed to diversity and inclusion. All qualified applicants will receive consideration without regard to race, color, religion, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, or other protected status. Reasonable accommodations will be provided to individuals with disabilities during the application and interview process, and for job functions.