Research Scientist, In Vitro

Priora; Greater London; On-site; Confidential; Full time

Benefits offered by this job

Wellness and lifestyle package

Gym membership support

Share option scheme

Pension contribution

Job summary

Priora in London is seeking a Research Scientist to execute on primary-cell culture and engineering workflows underpinning our in vitro research programme. You will isolate, culture and engineer primary immune cells, and produce viral vectors for genetic modification.

This highly hands-on role requires strong technical capability and collaborative working style to generate high-quality datasets guiding programme decisions.

Qualifications

• PhD in immunology or related field; exceptional Master’s candidates considered.
• Experience isolating and culturing primary immune cells within the last two years.
• Strong mammalian cell culture experience and hands-on cloning with virus production.
• Confident in running flow cytometry and cell sorting.
• Excellent communication and ability to work in a close-knit team.

Responsibilities

• Isolate and culture primary immune cells.
• Produce viral vectors and carry out cloning to support engineering work.
• Run multi-color flow cytometry, including sorting.
• Quantify activation, function and phenotype through assays.
• Keep cell culture running reliably for the team and troubleshoot issues.
• Collaborate with senior scientists to optimise workflows.

Skills

Primary immune cell culture

Mammalian cell culture

Flow cytometry

Cell sorting

Viral vector production

Cloning

Plasmid amplification

Scientific communication

Team collaboration

Education

PhD in immunology or related field

Master's degree with equivalent experience

Tools

ELN (Electronic Lab Notebook)

Flow cytometer (multicolor)

Molecular cloning techniques

Job description

We are looking for a Research Scientist to execute on the primary-cell culture and engineering workflows that underpin our in vitro research programme. You will isolate, culture and engineer primary immune cells, produce the viral vectors required for genetic modification, and perform the analytical and functional assays used to characterise cell phenotype and activity. Your work will provide the experimental foundation for a broad range of studies across the platform.

This is a highly hands-on bench-based role, working closely with our senior scientists and colleagues across the wider research team. You will be responsible not only for executing experiments, but also for maintaining robust and reproducible cell-culture systems, troubleshooting technical challenges and contributing to the optimisation of experimental workflows. You will work across primary-cell biology, molecular cloning, viral-vector production, flow cytometry and functional assay development, and will contribute directly to the generation of high-quality datasets used to guide programme decisions.

The role would suit a scientist who combines strong technical capability with careful experimental practice, enjoys working collaboratively, and takes pride in establishing reliable biological systems that others can build upon.

Tasks

• Isolate and culture primary immune cells
• Produce viral vectors and carry out the cloning that supports the engineering work
• Run multi-colour flow cytometry, including sorting
• Quantify activation, function and phenotype through reporter and functional assays
• Keep the cell-culture running reliably for the whole team

Requirements

You may be a good fit if you:

• Hold a PhD in immunology or a related field, such as bioscience or cell biology. Exceptional candidates with a Master’s degree and equivalent experience will also be considered
• Have isolated and cultured primary immune cells within the last two years
• Are strong in mammalian cell culture
• Have hands-on experience with plasmid amplification, cloning and virus production
• Are confident running flow cytometry and sorting
• Have strong communication skills and work well as part of a close-knit team

Strong candidates may also have experience with:

• Working with primary mouse cells alongside human material
• Working with adeno-associated virus (AAV)
• Isolating T cells from spleen and other primary tissue
• Working with engineered primary cell systems
• Co-culture and cell-killing assays
• Keeping a record of experimental planning and results in electronic lab notebooks (ELN)

Benefits

Highly competitive salary and pension contribution, alongside a wellness and lifestyle package that includes support towards gym membership and living close to the lab. All employees participate in the company share option scheme.