Research Scholar

eBanqo Inc; England; On-site; GBP 10,000 - 40,000; Full time

Job summary

An innovative research laboratory is seeking a motivated postdoc to explore the intricate mechanisms of cardiac muscle contraction. With access to cutting-edge Titan Krios TEMs and robust computing resources, this position offers a unique opportunity to contribute to groundbreaking research in structural biology. The ideal candidate will hold a Ph.D. in structural biology or a related field and possess a strong publication record. You will receive ample training and daily guidance from an experienced principal investigator, ensuring your professional growth in this exciting field. If you're passionate about advancing scientific knowledge and eager to make a meaningful impact, this role is perfect for you.

Qualifications

• Ph.D. in structural biology or muscle regulation required.
• At least one first author publication in a peer-reviewed journal.

Responsibilities

• Conduct research on cardiac muscle contraction mechanisms.
• Summarize data and write scientific papers for peer-reviewed journals.

Skills

Linux OS

Shell scripting

SPIDER programming

Python programming

UCSF Chimera

Phenix

IMODFIT

MD simulations software

Education

Ph.D. in Structural Biology

Tools

Titan Krios TEM

Falcon 3c

K3 summit direct detectors

SPIDER

EMAN2

RELION

Job description

Overview

Cryo electron microscopy laboratory (PI Dr. Vitold E. Galkin) is seeking motivated postdoc to conduct research on the mechanisms of cardiac muscle contraction. Dr. Galkin has excellent records of publications in the field of structural biology and pioneered single-particle approach to 3D reconstruction of helical filaments while working with Dr. Edward H. Egelman at UVA. PI has access to two state of the art Titan Krios TEMs equipped with Falcon 3c and K3 summit direct detectors, energy filters and phase plates. The nearest facility at UVA is within 2.5h by car. EVMS has TEM on site to conduct preliminary studies on protein complexes. PI has large park of Linux based work stations with 256-512Gb of memory and 36-48 core processors for high speed computing. SPIDER, EMAN2 and RELION software is used for classification and 3D-reconstruction. Position is offered for 3 years and is funded by the NIH R01 grant.

Qualifications

Ph.D. degree in structural biology or muscle regulation field is required. Applicant is expected to have at least one first author publication in international peer reviewed journal along with at least one record of participation in international meetings related to structural biology or muscle regulation. Fast learning curve is expected along with the ability to independently summarize data, relate results to the published observations and write scientific papers aimed for peer reviewed journals. An ample training will be provided and PI will be available to discuss progress on a daily basis during the first year.

Experience in the following areas will be prioritized:

1. Using Linux OS and writing shell scripts
2. Programming in SPIDER and Python
3. Using UCSF Chimera, Phenix and IMODFIT
4. Using any software related to MD simulations
5. Experience in studying muscle structure or muscle regulation

Location

US-VA-Norfolk