Research Fellow - Structural studies of neuronal protein-RNA complexes

UCL Eastman Dental Institute; London; On-site; GBP 38,000 - 41,000; Full time

Job summary

A leading research institute in London seeks a Research Fellow to explore the structural basis of protein-RNA interactions in neuronal development. This fixed-term position offers a competitive salary, substantial benefits, and the opportunity to conduct impactful research using cutting-edge biophysical methods.

Benefits

41 days holiday (27 days annual leave, 8 bank holidays, 6 closure days)

Defined benefit career average revalued earnings pension scheme (CARE)

Cycle to work scheme

Season ticket loan

Additional 5 days' annual leave purchase scheme

Qualifications

• PhD in Structural Biology required.
• Experience with Cryo-EM and knowledge of protein expression and purification.
• Ability to work within a team and contribute to scientific publications.

Responsibilities

• Conduct original research on protein-RNA recognition and regulation.
• Collaborate with other researchers and contribute to the research group.
• Publish results in scientific journals and present findings at conferences.

Skills

Cryo-EM

Protein expression

Purification

Education

PhD in Structural Biology

Job description

Social network you want to login/join with:

Research Fellow - Structural studies of neuronal protein-RNA complexes, London

Location: London, United Kingdom

Job Category: Other

EU work permit required: Yes

Job Reference: 44f92f8dd76b

Job Views: 4

Posted: 29.06.2025

Expiry Date: 13.08.2025

Job Description:

About the role

The role focuses on investigating the structural and molecular basis of protein-RNA recognition and regulation in neuronal development. Key questions include how RNA binding proteins recognize and remodel mRNA targets, and how these processes are regulated during neuronal development and in response to signaling.

The researcher will pursue original, multidisciplinary research, applying cryoEM and other biophysical methods to study protein-RNA structures and conformational changes. The role involves adapting cryoEM techniques for protein-RNA complexes and collaborating with other researchers, including active participation in the Ramos lab.

• This is a fixed-term position for 30 months from the start date.
• Appointment at Grade 7 requires a PhD; otherwise, initial appointment at Grade 6B (£38,000-£41,000 per annum), with backdated Grade 7 payment upon PhD completion.
• This position is subject to UCL Terms and Conditions of Service for Research and Professional Services Staff and Academic Staff.

About You

The successful candidate should have a PhD in Structural Biology with Cryo-EM experience, and knowledge of protein expression and purification. Experience with other biophysical and structural methods is beneficial. The candidate will work within a team to advance understanding of RNA regulators in neuronal development, focusing initially on the IGFBP1/IMP1 system. Responsibilities include conducting research, contributing to the research group, publishing in scientific journals, and presenting at conferences.

What We Offer

Benefits include:

• 41 days holiday (27 days annual leave, 8 bank holidays, 6 closure days)
• Additional 5 days' annual leave purchase scheme
• Defined benefit career average revalued earnings pension scheme (CARE)
• Cycle to work scheme and season ticket loan