Research Fellow (Post doctoral) - School of BiosciencesGrade 7. Job in Birmingham Education & T[...]

The University of Birmingham; Birmingham; On-site; GBP 36,000 - 46,000; Full time

Job summary

The University of Birmingham seeks a Postdoctoral Research Fellow in structural biology to join a Wellcome Trust funded project focused on RNA metabolism and gene regulation. This role offers access to premier research facilities and an interdisciplinary environment for groundbreaking scientific inquiry, with a commitment to personal and professional development.

Benefits

Access to state-of-the-art facilities

Professional development opportunities

Collaborative research environment

Qualifications

• Higher degree relevant to research area (Structural Biology, Biochemistry, Biophysics).
• Proficiency in techniques like Cryo-EM, NMR, and X-ray Crystallography.
• Experience in protein expression and purification.

Responsibilities

• Conduct experiments and analyze data to achieve research objectives.
• Develop proposals for research projects and contribute to funding bids.
• Supervise students on research-related work.

Skills

Bioinformatics

Biochemistry

Cell Biology

Molecular Biology

Data Analysis Skills

Education

PhD in Structural Biology or Biophysics

First Degree in Chemistry, Biochemistry, or Biophysics

Tools

NMR Spectroscopy

Cryo-Electron Microscopy

X-ray Crystallography

Job description

Description

Position Details

School of Biosciences

Location: University of Birmingham Edgbaston Birmingham UK

Full time starting salary is normally in the range 36130 to 45413 with potential progression once in post to 48149

Grade: 7

Full Time Fixed Term contract up to July 2028

Closing date: 18th June 2025

Open House Drop In Session:We will be holding an open house drop in session at the Universitys Exchange building in Centenary Square Birmingham between 10am and 5pm on Friday 6th June 2025. If youre interested in working at the University of Birmingham and perhaps have a few questions this is an opportunity to meet colleagues in the Recruitment team. It will be a relaxed and informal event you can drop in at any time.

Background

A Wellcome Trust funded Post doctoral Research Fellow position is available in structural biology utilizing Cryo-EM NMR and X-ray crystallography along with biochemistry cell biology and RNA biology. The position will be based in the research group of Dr. Pravin Jagtap ( ) at the University of Birmingham UK. The Research Fellow will work in the field of RNA metabolism and regulation of gene expression to understand the regulatory mechanisms mediated by accessory domains in human RNA helicases involved in cancer and neurodegenerative diseases. We offer unique access to first-class instrumentation for structural the Midlands Regional Cryo Electron Microscope Facility in Leicester you will have access to a 300kV Titan Krios G3 cryo-electron microscope with a direct electron-detecting camera. We have BAG access to the synchrotron at DIAMOND for small angle scattering and X-ray crystallography. At the national centre for biomolecular NMR spectroscopy in Birmingham (HWB-NMR) we host the best biomolecular NMR equipment available in the UK comprising 1000 and 900 MHz spectrometers equipped with cryoprobes and MAS probes for both solution- and solid-state NMR as well as an incoming 1.2 GHz spectrometer expected in spring 2025. Fully equipped biochemistry and molecular biology laboratories as well as extensive equipment for in cellulo work and light microscopy are available. This interdisciplinary research environment will provide you with unique development opportunities.

This project is a part of a larger project which will involve two other postdocs and two PhD students in the coming years within a Wellcome Trust Career Development award funded research programme Unlocking the RNA Helicase Code: From Structural Insights to Therapeutic Strategies led by Dr. Jagtap. The overall project builds upon our novel and exciting findings on the regulation of RNA helicases by accessory RNA bindind domains providing an opportunity to target the RNA helicases involved in cancer and neurodegeneration in humanswith small molecules and peptides without affecting the highly conserved ATP and RNA binding sites (Lang N. . RNA biology 21 2025; Jagtap PKA . Mol Cell 83 2024 Jagtap PKA . NAR 47 2019).

Role Summary

• Work within specified research grants and projects and contribute to writing bids
• Operate within area of specialism
• Design and perform experiments
• Analyse and interpret research findings and results
• Contribute to generating funding
• Contribute to licensing or spin out deals with demonstrated commercial success (such as revenues asset or company sales IP generated) and/or public understanding of the discipline or similar

Main Duties

The responsibilities may include some but not all of the responsibilities outlined below.

• Conduct experiments troubleshoot and analyse data under supervision todeliver on this Wellcome Trust research goals
• Develop research objectives and proposals for own or joint research in the area of interest of the hosting laboratory
• Contribute to writing bids for research funding
• Acquire analyse and interpret data structural biology biochemical and biophysical data.
• Apply knowledge in a way which develops new intellectual understanding
• Disseminate research findings for publication research seminars etc
• Supervise students on research related work and provide guidance to PhD students where appropriate to the discipline
• Contribute to developing new models techniques and methods
• Undertake management/administration arising from research
• Contribute to Departmental/School research-related activities and research-related administration
• Contribute to enterprise business development and/or public engagement activities of manifest benefit to the College and the University often under supervision of a project leader
• Collect research data; this may be through a variety of research methods such as scientific experimentation and literature reviews
• Present research outputs including drafting academic publications or parts thereof for example at seminars and as posters
• Deal with problems that may affect the achievement of research objectives and deadlines
• Promotes equality and values diversity acting as a role model and fostering an inclusive working culture.

Person Specification

• First degree in Chemistry Biochemistry or Biophysics (or in any closely related area) andnormally a higher degree relevant to research area (Structural biology biochemistry and biophysics) or equivalent qualifications
• PhD (or near to completion) in relevant subject area (structural biology or biophysics)
• Proficiency in at least one of these techniques (e.g. single-particle electron microscopy NMR spectroscopy X-ray crystallography small-angle scattering) and willingness to learn others
• Experience in protein expression (bacterial insect or mammalian cells) protein purification and nucleic acid handling
• Experience with biophysical techniques for characterisation of protein-RNA protein-protein and protein small molecule interactions
• Strong analytical skills and the ability to communicate complex information effectively
• Familiarity with research techniques and the ability to contribute to their development
• Ability to manage resources efficiently and coordinate work with others
• Willingness to work in an international competitive research environment
• High level analytical capability
• Ability to communicate complex information clearly
• Fluency in relevant models techniques or methods and ability to contribute to developing new ones
• Ability to assess resource requirements and use resources effectively
• Contribute to the planning and organising of the research programme and/or specific research project
• Co-ordinate own work with others to avoid conflict or duplication of effort
• Knowledge of the protected characteristics of the Equality Act 2010 and how to actively ensure in day to day activity in own area that those with protected characteristics are treated equally and fairly

Informal enquiries to Dr. Pravin Jagtap email:

We believe there is no such thing as a typical member of University of Birmingham staff and that diversity in its many forms is a strength that underpins the exchange of ideas innovation and debate at the heart of University life. We are committed to proactively addressing the barriers experienced by some groups in our community and are proud to hold Athena SWAN Race Equality Charter and Disability Confident accreditations. We have an Equality Diversity and Inclusion Centre that focuses on continuously improving the University as a fair and inclusive place to work where everyone has the opportunity to succeed. We are also committed to sustainability which is a key part of our strategy. You can find out more about our work to create a fairer university for everyone on our website.

Key Skills
Bioinformatics,Genetics,R,Biochemistry,Cell Biology,Research Experience,Statistical Software,Cell Culture,Molecular Biology,Data Analysis Skills,Flow Cytometry,Microscopy
Employment Type : Full-Time
Experience: years
Vacancy: 1
Monthly Salary Salary: 36130 - 45413