Research Associate- Welch Group: Global reprogramming of virulence and AMR in Pseudomonas aerug[...]

TN United Kingdom; Cambridge; On-site; GBP 30,000 - 50,000; Full time

Job summary

An established industry player is seeking a Research Associate to join a dynamic team focused on understanding antimicrobial resistance mechanisms in Pseudomonas aeruginosa. This exciting role involves cutting-edge research utilizing advanced techniques like RNA-seq and proteomics to explore how specific mutations contribute to antibiotic resistance. The position offers the opportunity to collaborate with leading experts and engage in international research, all while contributing to vital studies that can improve health outcomes for vulnerable populations. If you are passionate about biochemistry and eager to make a significant impact, this is the perfect opportunity for you.

Qualifications

• Strong background in molecular biology and biochemistry.
• Experience with high-throughput sequencing technologies.

Responsibilities

• Conduct research on mutations in fusA1 and their impact on antibiotic resistance.
• Collaborate with international teams and travel for research purposes.

Skills

RNA-seq

Ribo-seq

ChIP-seq

Biochemical assays

Structural analyses

Proteomics

Education

PhD in Biochemistry or related field

Tools

TurboID

OOPS proteomics

Job description

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Research Associate - Welch Group: Global reprogramming of virulence and AMR in Pseudomonas aeruginosa by mutations in FusA1 (Fixed Term), Cambridge

Client:

University of Cambridge

Location:

Cambridge, United Kingdom

Job Category:

Other

EU work permit required:

Yes

Job Reference:

1d373fe9c2b1

Job Views:

4

Posted:

05.05.2025

Expiry Date:

19.06.2025

Job Description:

Applications are invited for a Research Associate position in the laboratory of Professor Martin Welch in the Department of Biochemistry, University of Cambridge.

Mutations in fusA1 are responsible for high-level resistance to aminoglycoside antibiotics, especially in the pathogen Pseudomonas aeruginosa. These mutations are common in environments and pose significant health risks, particularly for immunocompromised individuals and those with genetic predispositions like cystic fibrosis.

The project aims to understand how fusA1 mutations lead to antimicrobial resistance (AMR). FusA1 encodes a ribosome recycling factor critical for proper translation. Mutations may impair this function, causing ribosomal stalling and queueing, which could influence resistance mechanisms.

The research will utilize RNA-seq, Ribo-seq, ChIP-seq, structural analyses, TurboID, OOPS proteomics, and biochemical assays. The role involves collaboration across laboratories and international travel.

The University emphasizes research merit over publication metrics, aligning with DORA principles. The position is fixed-term, from 01 March 2025 to 29 February 2028. Informal inquiries can be directed to Professor Martin Welch. The university supports diversity and inclusion and ensures employment eligibility in the UK.