Research Associate - Jackson (Fixed Term)

University of Cambridge; Cambridge; On-site; GBP 30,000 - 38,000; Full time

Job summary

The University of Cambridge is seeking a Research Associate in the Department of Biochemistry. The successful candidate will conduct a funded project on voltage-gated sodium channels and engage in experiments and analysis with a focus on drug interactions. Candidates should possess a PhD and extensive experience in biochemistry and electrophysiology.

Qualifications

• Expert knowledge of voltage-gated sodium channels.
• Experience in manual and automated patch clamp electrophysiology.
• Molecular biology experience for cloning and site-directed mutagenesis.

Responsibilities

• Conduct a BHF-funded research project on Nav1.5 channels.
• Design and interpret experiments alongside research team.
• Publish findings in journal articles and present at conferences.

Skills

Electrophysiology

Molecular Biology

Computational Modelling

Cryo Electron Microscopy

Education

PhD in Biochemistry

Job description

Applications are invited for a Research Associate to join the Department of Biochemistry, under the supervision of Dr Antony Jackson. The successful candidate will conduct a BHF-funded research project on voltage-gated sodium channels, particularly the heart-specific channel, Nav1.5. The specific question will focus on the functional effects of small molecule drugs on Nav channel behaviour. The work will entail electrophysiological analysis, structural biology approaches such as cryo electron microscopy, computational modelling, cell biology and biochemistry.

The role holder will therefore need to possess expert knowledge on the structure and function of voltage-gated sodium channels and skills in both manual and automated patch clamp electrophysiology. Molecular biology experience for the cloning, site-directed mutagenesis and expression of Nav channels will be required, together with experience of computational modelling for drug docking to aid mutagenesis experiments.

The successful candidate will help design, conduct and interpret experiments in discussion with the PI and Co-PI and other members of the research team. Research will be presented at group meetings and at research conferences and will be published in journal articles prepared by the role holder, with support from other team members.

Candidates should hold a PhD in Biochemistry or another relevant subject.

Fixed-term: The funds for this post are available from 7th November 2025 until 30th June 2027, in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are welcome to be sent to Dr Antony Jackson: [e-mail]

For queries regarding the application process, please contact: [e-mail]

Please quote reference PH46147 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Further information

• Further Particulars - Research Associate - Jackson