Research Associate in Physical Biology - Mitotic Mechanisms

University of Cambridge; Cambridge; On-site; GBP 34,000 - 42,000; Full time

Job summary

The University of Cambridge's Sainsbury Laboratory invites applications for a Post-doctoral Research Associate in computational biology. The project studies chromosome segregation and spindle mechanics using mathematical models and computer simulations within the BioMecaNet ERC Synergy framework.

The successful candidate will develop quantitative models, perform large-scale simulations, and contribute to publications. Opportunities to supervise students and engage in teaching are available.

Qualifications

• PhD in a relevant field or nearing completion.
• Proven record of scientific publications.
• Experience modelling biological systems or theoretical biophysics advantageous.
• Excellent communication skills and ability to present work.

Responsibilities

• Develop mathematical models and advanced numerical simulations.
• Collaborate with experimental groups and supervise student projects.
• Write up research findings for publications and presentations.

Skills

PhD in related field

Publication record

Mathematical modelling

Machine learning

Education

PhD in Computational Biology or related field

Tools

Python

MATLAB

NumPy/SciPy

Job description

Applications are invited for a Post-doctoral Research Associate position in the group of Dr. Francois Nedelec at the Sainsbury Laboratory Cambridge University (SLCU). This call is open to carry out fundamental research in the field of physical biology, specifically studying mitotic spindle assembly and chromosome segregation. This post is funded by a prestigious ERC Synergy project BioMecaNet in collaboration with the experimental groups of Andrea Musacchio (MPI of Molecular Physiology, Dortmund, DE) and Thomas Surrey (CRG, Barcelona, SP).The project's primary focus is the comprehensive analysis of the fundamental mechanisms underlying chromosome segregation, employing advanced mathematical models and computer simulations. The research will concentrate on a thorough investigation into the mechanics of the cytoskeleton, particularly in relation to the formation of a functional bipolar mitotic spindle.A central goal of the project is to integrate filament mechanics and cellular chemistry into the modeling process, with a specific aim to develop physically accurate simulations of chromosome bi-orientation and segregation.Applicants must have or be close to obtaining a PhD in computational biology, physics, applied mathematics, computer science or related field and have a proven track record of scientific publication. Prior experience in modelling of biological systems, or expertise in systems biology and/or theoretical biophysics, in general, would be advantageous. The successful applicant will have the opportunity to develop skills in mathematical modelling, advanced numerical simulations and machine learning.Fully involved in the basic research in these areas whilst also writing up their research work for presentation and publication, the post holder will have the opportunity to assist in the supervision of student projects, and to engage in teaching if desired. Good and effective communication skills are essential (e.g. presentations, outreach activities).The Laboratory provides a welcoming and collaborative environment with a wide range of family-friendly benefits and development opportunities. More about the Sainsbury Laboratory and details of what the University offers to employees, can be found at: http://www.slcu.cam.ac.uk/.Please ensure that you upload a copy of your full CV with publications list, cover letter highlighting your suitability for the position and contact information of three referees.Fixed-term: The funds for this post are available until 30 June 2028.Scientific enquiries apart from the formal application should be directed to Dr Francois Nedelec at [e-mail] questions regarding the application process, please email [e-mail] quote reference PT51399 on your application and in any correspondence about this vacancy.The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.The University has a responsibility to ensure that all employees are eligible to live and work in the UK.Apply online