Research Associate in Oligonucleotide Disposition

TN United Kingdom; Manchester; On-site; GBP 30,000 - 40,000; Full time

Job summary

A leading university in Manchester is seeking a Research Associate in Oligonucleotide Disposition for a 24-month fixed-term position. The role involves developing in vitro assays and contributing to PBPK modelling projects, requiring a PhD in biomedical or pharmaceutical research and relevant experience in molecular techniques.

Benefits

Market-leading pension scheme

Employee health and wellbeing services

Generous annual leave and bank holidays

Additional paid closure over Christmas

Discounts at major retailers

Qualifications

• PhD in biomedical or pharmaceutical research required.
• Experience in establishing cell-based assays and molecular techniques like RT-PCR and ELISA.
• Desirable experience with proteomic analyses and mathematical modelling.

Responsibilities

• Establish novel in vitro assays to quantify siRNA uptake and distribution.
• Develop methods using techniques such as subcellular fractionation and live-cell imaging.
• Inform PBPK-PD models for predicting in vivo oligonucleotide disposition.

Skills

Establishing cell-based assays

Molecular techniques

Proteomic analyses

Mathematical modelling

Working in multidisciplinary teams

Education

PhD in biomedical or pharmaceutical research

Job description

Research Associate in Oligonucleotide Disposition, Manchester

Client: The University Of Manchester

Location: Manchester, United Kingdom

Job Category: Other

EU work permit required: Yes

Job Reference: 01c3d580c9ec

Job Views: 4

Posted: 23.05.2025

Expiry Date: 07.07.2025

Job Description:

Applications are invited for a Research Associate in Oligonucleotide Disposition at the Centre for Applied Pharmacokinetic Research (CAPKR) within the Division of Pharmacy and Optometry. The position is fixed-term for 24 months. The successful candidate will establish novel in vitro assays to quantify siRNA uptake, distribution, and effects in primary cultured hepatocytes. These data will inform PBPK-PD models for predicting in vivo oligonucleotide disposition and effects. The research involves developing and exploring in vitro methods using techniques such as subcellular fractionation, live-cell imaging, RT-PCR, and ELISA.

The candidate will join the CAPKR research team on a project titled “Improving a priori PBPK modelling for translation of oligonucleotide disposition, tissue clearance, and durability of effect”. The ideal applicant should hold a PhD in biomedical or pharmaceutical research, with experience in establishing cell-based assays and molecular techniques like RT-PCR and ELISA. Experience with proteomic analyses, mathematical modelling, and working in multidisciplinary teams is desirable.

This research role requires applicants who are not EEA nationals or from exempt countries to obtain an ATAS certificate prior to applying for a UK visa under the Skilled Worker route.

What you will get in return:

• Market-leading pension scheme
• Employee health and wellbeing services including an Employee Assistance Programme
• Generous annual leave and bank holidays
• Additional paid closure over Christmas
• Discounts at major retailers