This is a full-time position until 31st December 2027, suitable for a talented imaging scientist, who wants to join an international team investigating the impact of proton beam therapy on the brain.
Long-term survival after childhood brain tumour treatment has reached an all-time high of 75%. However, despite the evolution of more spatially targeted radiotherapy methods and modalities such as proton beam therapy, almost two-thirds of these children develop neurologic, hypothalamic / pituitary, and cognitive problems. In the Brainatomy2 project (https://www.mcrc.manchester.ac.uk/brainatomy-2/) we aim to improve outcomes for these children. One part of this research is to use quantitative MRI to understand the long-term impact of proton beam therapy on the brain. We will recruit 150 children and young adults who have undergone proton beam therapy at least 5 years previously.
The Research Associate employed in this role will use advanced MRI techniques of high angular resolution diffusion-weighted imaging (DWI), arterial spin labelling (ASL) and functional MRI to detect changes to the brain microstructure and microvasculature and evaluate how these changes relate to cognitive deficits. Radiation dose-maps will be used to consider the impact of radiation on subsequent alterations in regional brain volume, blood flow and microstructure.
You will work with an international team of leading experts in brain tumour research including oncologists, radiation physicists, neuroradiologists and cognitive neuroscientists.
What you will get in return: