Research Associate in In Vitro siRNA Disposition

The University of Manchester; Manchester; Hybrid; GBP 60,000 - 80,000; Full time

Job summary

A leading research institution in Manchester seeks a Research Associate to focus on oligonucleotide disposition. You will develop in vitro assays and contribute to PBPK modelling based on siRNA research. Candidates should hold a PhD in biomedical or pharmaceutical research and have relevant experience. This role offers a competitive pension scheme and generous leave, with flexible working arrangements available.

Benefits

Market-leading pension scheme

Employee health and wellbeing services

Generous annual leave entitlement

Paid closure over Christmas

Discounts at major retailers

Qualifications

• Experience establishing cell-based assays and molecular techniques is essential.
• Experience in proteomic analyses and mathematical modelling is desirable.
• Ability to work in multidisciplinary teams is an asset.

Responsibilities

• Establish novel in vitro assays to quantify siRNA uptake and intracellular distribution.
• Develop methods for predicting in vivo oligonucleotide disposition and effects.
• Join the research team and contribute to PBPK modelling projects.

Skills

Establishing cell-based assays

Molecular techniques

Proteomic analyses

Mathematical modelling

Working in multidisciplinary teams

Education

PhD in biomedical or pharmaceutical research

Tools

RT-PCR

ELISA techniques

Live-cell imaging

Job description

Applications are invited for a Research Associate in Oligonucleotide Disposition at the Centre for Applied Pharmacokinetic Research (CAPKR) within the Division of Pharmacy and Optometry. The position is fixed-term for 24 months.

The post-doctoral research associate will establish novel in vitro assays to quantify siRNA uptake, intracellular distribution, and effects in primary cultured hepatocytes. These data will inform mechanistic PBPK-PD models for predicting in vivo oligonucleotide disposition and effects. The research involves developing and exploring in vitro methods, including subcellular fractionation, live-cell imaging, RT-PCR, and ELISA techniques.

The successful candidate will join the CAPKR research team and work on a project titled "Improving a priori PBPK modelling for translation of oligonucleotide disposition, tissue clearance, and durability of effect." Applicants should hold a PhD in biomedical or pharmaceutical research and have experience establishing cell-based assays and molecular techniques. Experience with proteomic analyses, mathematical modelling, and working in multidisciplinary teams is desirable.

Applicants who are not EEA nationals or from exempt countries and require UK visa sponsorship must apply for an ATAS certificate before applying for the role.

What you will get in return:

• Market-leading pension scheme
• Employee health and wellbeing services, including an Employee Assistance Programme
• Generous annual leave entitlement plus bank holidays
• Paid closure over Christmas
• Discounts at major retailers

We are an equal opportunities employer and welcome applicants from all backgrounds. We support flexible working arrangements, including hybrid work.

Note: We do not accept CVs or applications via recruitment agencies. Enquiries should be directed to [e-mail]. For vacancy-specific questions, contact Daniel Scotcher at [e-mail]. General enquiries can be sent to [e-mail]. Technical support is available at https://jobseekersupport.jobtrain.co.uk/support/home.

This vacancy closes at midnight on the specified closing date. Please see the Further Particulars document for person specification criteria.