Research Associate in in Neuro-Immunology and Extraceullar Matrix Biology (ImmunoMatrix)

The University of Manchester; Manchester; Hybrid; GBP 80,000 - 100,000; Full time

Job summary

A prestigious research institution in Manchester is seeking a Research Associate in Neuro-Immunology and Extracellular Matrix Biology. The ideal candidate will engage in cutting-edge research to understand immune cell dynamics in the brain's inflammation processes, utilizing advanced techniques such as intravital imaging. This full-time role offers exceptional benefits including a leading pension scheme and extensive leave entitlements, fostering an inclusive work environment. Hybrid working arrangements may be considered.

Benefits

Fantastic market leading Pension scheme

Excellent employee health and wellbeing services

Exceptional starting annual leave

Local and national discounts

Qualifications

• Experience in immunology or related field is required.
• Experience with clinical samples for relevance to human pathology.
• A strong understanding of immune cell dynamics.

Responsibilities

• Analyze the role of glycocalyx on immune cell recruitment.
• Conduct experiments using stroke as a preclinical model.
• Combine preclinical findings with clinical relevance.

Skills

Intravital imaging

Flow-cytometry

Immunofluorescence

Job description

Overview

Research Associate in Neuro-Immunology and Extracellular Matrix Biology (ImmunoMatrix) – University of Manchester

Location: Manchester • Type: Permanent • Hours: Full-time

Posted: 22 hours ago

About the role

There is exquisite control of immune cell recruitment to all bodily tissues. In injury and disease, such control is important to appropriately resolve the insult or infection whilst limiting inflammation that can drive pathology. In the brain, this takes on critical significance, as central nervous system neurons do not regenerate, therefore limiting damage by infiltrating inflammatory immune cells is crucial to retain function. Chemokines are molecules that mediate immune cell recruitment, and are heavily implicated in pathological brain inflammation, but have not been successfully therapeutically targeted during inflammation due to limited understanding of their basic biology.

Our Glyco-Immunology (Dyer) lab has produced published and preliminary data demonstrating that an under-appreciated structure, the glycocalyx, on endothelial- and immune- cells regulates immune cell recruitment by:

• Physically regulating the interaction between endothelial and immune cells, that is required for recruitment into the inflamed brain.
• Containing proteoglycans that can directly act as chemokine receptors to drive immune cell recruitment during pathological neuroinflammation.

This position will transform our understanding of how the glycocalyx regulates cell trafficking to the inflamed brain, using stroke as a model condition. During this position, the post-holder will undertake a range of activities including a multi-disciplinary approach (intravital imaging, flow-cytometry and immunofluorescence) to analyse the role of the glycocalyx on different cells and chemokines in orchestrating recruitment of immune cells to the brain during inflammation. Initially this will focus on using stroke as a preclinical disease model. These approaches will also be combined with analysis of samples from human patients for clinical relevance.

What you will get in return

• Fantastic market leading Pension scheme
• Excellent employee health and wellbeing services including an Employee Assistance Programme
• Exceptional starting annual leave entitlement, plus bank holidays
• Additional paid closure over the Christmas period
• Local and national discounts at a range of major retailers

Equal opportunity statement

As an equal opportunities employer we support an inclusive working environment and welcome applicants from all sections of the community regardless of age, disability, ethnicity, gender, gender expression, religion or belief, sex, sexual orientation and transgender status. All appointments are made on merit. Our University is positive about flexible working - you can find out more. Hybrid working arrangements may be considered.

Applications and contact

Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies. Any CV's submitted by a recruitment agency will be considered a gift.

Enquiries about the vacancy, shortlisting and interviews:

• Name: Dr Douglas Dyer
• Email: General enquiries: [Email]
• Technical support: [Email]

This vacancy will close for applications at midnight on the closing date. Please see the link below for the Further Particulars document which contains the person specification criteria. Please be aware that due to the number of applications we are unfortunately not able to provide individual feedback on your application.

University of Manchester