Enable job alerts via email!
Research Associate Fellow in Respiratory Medicine
Guy's and St Thomas' NHS Foundation Trust
London
On-site
GBP 30,000 - 40,000
Full time
2 days ago
Be an early applicant
Generate a tailored resume in minutes
Land an interview and earn more. Learn more
Start fresh or import an existing resume
Job summary
Guy's and St Thomas' NHS Foundation Trust is seeking a postdoctoral research associate for a project focusing on bronchiectasis at the Royal Brompton Hospital. The role involves a range of research activities including data analysis, supervising students, and conducting lab experiments. Candidates should possess a PhD in immunology, be familiar with laboratory techniques, and demonstrate excellent teamwork skills.
Qualifications
- Work independently in general lab techniques, including cell culture, qPCR, ELISA, and data analysis.
- Prior experience in analyzing large datasets and using R or similar packages is desirable.
Responsibilities
- Conduct research on bronchiectasis and direct small research teams.
- Participate in the planning and execution of research initiatives.
- Present findings to colleagues and assist PhD students.
Skills
Independence in laboratory techniques
Data analysis skills
Competence in cell culture
Education
PhD in immunology or related field
Primary degree in health or biology related subject
Job description
Job summary
Department Information
This post will be situated between the respiratory infection department at the Royal Brompton hospital, Guy's and St. Thomas' NHS Foundation trust and the Shah/Singanayagam laboratories at the Centre of Bacterial Resistance Biology, Imperial College London. The Royal Brompton hospital has the largest cohort of patients with bronchiectasis in Europe with ~2000 individuals with bronchiectasis related to a number of aetiologies including idiopathic, primary and secondary immunodeficiency, primary ciliary dyskinesia, allergic bronchopulmonary aspergillosis and cystic fibrosis.
Main duties of the job
1. Duties and Responsibilities
To actively participate in the research programme of the Group
To participate in Group research meetings and internal seminars
To contribute to the smooth running of the Group's laboratories and, facilities with other scientists, clinicians, technicians and students within the laboratories
Assist in the supervision of undergraduate and postgraduate research students and research assistants as required
Any other duties as may be deemed reasonable by Head of group as well as Head of Division/Department/Section
About us
Organisational Values:
Our values help us to define and develop our culture, what we do and how we do it. It is important that you understand andreflect these values throughout your employment with the Trust.
The post holder will be:
Caring - we put patients first
Ambitious - we innovate and strive for excellence
Inclusive - we respect each other and work collaboratively
Our values and behaviours framework|describes what it means for every one of us in the Trust to put our values into action.
Job description
Job responsibilities
1. Job Summary
The post will be jointly supervised between Dr Anand Shah and Dr Aran Singanayagam. This is a 18 month post funded by an industry collaboration to identify the molecular pathways relevant to disease pathophysiology in the chronic respiratory condition bronchiectasis. The post will use existing ethically approved research projects to obtain clinical samples including upper and lower airway samples from individuals with chronic respiratory disease with a focus on bronchiectasis. A key aspect of the project will be to expand bronchial epithelial samples to be used within multiple analysis techniques and/or assays. In particular, the cultured cells will be used to create different models of disease such air-liquid interface cultures which can be used to study responses both before and after administration of different stimuli (e.g. pathogens or inflammatory ligands) and/or candidate molecules
We are aiming to recruit an enthusiastic, dynamic, and motivated postdoctoral research associate with an interest in host-pathogen interactions, who wishes to expand their research portfolio. You will join an exciting multidisciplinary group with expertise in immunology and molecular microbiology. The post holder will be required to work both individually and as a team and may be required to teach more junior members of the laboratory. You should integrate with the group with a cooperative, enthusiastic and flexible approach.
Essential Requirements:
PhD in immunology or equivalent vocational qualification
Work independently and be competent in general lab techniques, including cell culture, qPCR, ELISA, WB, bioinformatics and data analysis.
Desirable Requirements:
Prior experience in epithelial cell culture including air-liquid interface and/or pulmonary organoid models
Prior experience in analysis of large sequencing datasets (bulk RNA-seq) with associated competence in using R or similar analysis packages.
2. Key Relationships
The postholder will be integrated into the research group led by Dr Anand Shah and Dr Aran Singanayagam with a clinical translational research role across the Royal Brompton hospital and the Centre of Bacterial Resistance Biology, Imperial College London.
Selected papers from the Shah/Singanayagam lab
Almond M, Farne H, K, Jackson MM, Jha A, Katsoulis O (et al)Johnston SL, Singanayagam A. Obesity dysregulates the pulmonary antiviral immune response. Nature Communications 2023. 14: 6607.
George PM, Reed A, Desai S, Devaraj A, Faiez TS, (et al)Shah A, Singanayagam A. A persistent neutrophil-associated immune signature characterises post-COVID19 pulmonary sequelae. Science Translational Medicine. 2022; 14: 671
Singanayagam A, Foottit J, Marcyzynski M, Radicioni G, Cross MT et al. Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease. J Clin Invest 2022; 132: e120901.
Kamal F, Kumar S, Edwards MR, Veselkov K, Belluomo I, (et al.).Singanayagam A, Hanna GB*. Virus-induced volatile organic compounds are detectable in exhaled breath during pulmonary infection. Am J Respir Crit Care Med 2021. 204: 1075-85.
Finney L, Glanville N, Farne H, Aniscenko J, Fenwick P, (et al.)Johnston SL, Singanayagam A. Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon. J Allerg Clin Immunol 2021; 147: 510-19.
3. Duties and Responsibilities
To actively participate in the research programme of the Group
To participate in Group research meetings and internal seminars
To contribute to the smooth running of the Groups laboratories and, facilities with other scientists, clinicians, technicians and students within the laboratories
Assist in the supervision of undergraduate and postgraduate research students and research assistants as required
Any other duties as may be deemed reasonable by Head of group as well as Head of Division/Department/Section
Job description
Job responsibilities
1. Job Summary
The post will be jointly supervised between Dr Anand Shah and Dr Aran Singanayagam. This is a 18 month post funded by an industry collaboration to identify the molecular pathways relevant to disease pathophysiology in the chronic respiratory condition bronchiectasis. The post will use existing ethically approved research projects to obtain clinical samples including upper and lower airway samples from individuals with chronic respiratory disease with a focus on bronchiectasis. A key aspect of the project will be to expand bronchial epithelial samples to be used within multiple analysis techniques and/or assays. In particular, the cultured cells will be used to create different models of disease such air-liquid interface cultures which can be used to study responses both before and after administration of different stimuli (e.g. pathogens or inflammatory ligands) and/or candidate molecules
We are aiming to recruit an enthusiastic, dynamic, and motivated postdoctoral research associate with an interest in host-pathogen interactions, who wishes to expand their research portfolio. You will join an exciting multidisciplinary group with expertise in immunology and molecular microbiology. The post holder will be required to work both individually and as a team and may be required to teach more junior members of the laboratory. You should integrate with the group with a cooperative, enthusiastic and flexible approach.
Essential Requirements:
PhD in immunology or equivalent vocational qualification
Work independently and be competent in general lab techniques, including cell culture, qPCR, ELISA, WB, bioinformatics and data analysis.
Desirable Requirements:
Prior experience in epithelial cell culture including air-liquid interface and/or pulmonary organoid models
Prior experience in analysis of large sequencing datasets (bulk RNA-seq) with associated competence in using R or similar analysis packages.
2. Key Relationships
The postholder will be integrated into the research group led by Dr Anand Shah and Dr Aran Singanayagam with a clinical translational research role across the Royal Brompton hospital and the Centre of Bacterial Resistance Biology, Imperial College London.
Selected papers from the Shah/Singanayagam lab
Almond M, Farne H, K, Jackson MM, Jha A, Katsoulis O (et al)Johnston SL, Singanayagam A. Obesity dysregulates the pulmonary antiviral immune response. Nature Communications 2023. 14: 6607.
George PM, Reed A, Desai S, Devaraj A, Faiez TS, (et al)Shah A, Singanayagam A. A persistent neutrophil-associated immune signature characterises post-COVID19 pulmonary sequelae. Science Translational Medicine. 2022; 14: 671
Singanayagam A, Foottit J, Marcyzynski M, Radicioni G, Cross MT et al. Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease. J Clin Invest 2022; 132: e120901.
Kamal F, Kumar S, Edwards MR, Veselkov K, Belluomo I, (et al.).Singanayagam A, Hanna GB*. Virus-induced volatile organic compounds are detectable in exhaled breath during pulmonary infection. Am J Respir Crit Care Med 2021. 204: 1075-85.
Finney L, Glanville N, Farne H, Aniscenko J, Fenwick P, (et al.)Johnston SL, Singanayagam A. Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon. J Allerg Clin Immunol 2021; 147: 510-19.
3. Duties and Responsibilities
To actively participate in the research programme of the Group
To participate in Group research meetings and internal seminars
To contribute to the smooth running of the Groups laboratories and, facilities with other scientists, clinicians, technicians and students within the laboratories
Assist in the supervision of undergraduate and postgraduate research students and research assistants as required
Any other duties as may be deemed reasonable by Head of group as well as Head of Division/Department/Section
Person Specification
Qualifications/ Education
Essential
Essential
Essential
Qualifications/ Education
Essential
Essential
Essential
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Certificate of Sponsorship
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the .
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. .
Additional information
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Certificate of Sponsorship
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the .
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. .
Employer details
Employer name
Guy's and St Thomas' NHS Foundation Trust
Address
Royal Brompton Hospital and Centre of Bacterial Resistance Biology, Imperial College London
London
SW3 6NP
Employer's website
Department Information
This post will be situated between the respiratory infection department at the Royal Brompton hospital, Guy's and St. Thomas' NHS Foundation trust and the Shah/Singanayagam laboratories at the Centre of Bacterial Resistance Biology, Imperial College London. The Royal Brompton hospital has the largest cohort of patients with bronchiectasis in Europe with ~2000 individuals with bronchiectasis related to a number of aetiologies including idiopathic, primary and secondary immunodeficiency, primary ciliary dyskinesia, allergic bronchopulmonary aspergillosis and cystic fibrosis.
Main duties of the job
1. Duties and Responsibilities
- To take initiatives in the planning of research
- To direct the work of small research teams
- To conduct data analysis
- To write reports for submission to research sponsors
- To present findings to colleagues and at conferences
- To submit publications to refereed journals
- To provide guidance to PhD Students
To actively participate in the research programme of the Group
To participate in Group research meetings and internal seminars
To contribute to the smooth running of the Group's laboratories and, facilities with other scientists, clinicians, technicians and students within the laboratories
Assist in the supervision of undergraduate and postgraduate research students and research assistants as required
Any other duties as may be deemed reasonable by Head of group as well as Head of Division/Department/Section
About us
Organisational Values:
Our values help us to define and develop our culture, what we do and how we do it. It is important that you understand andreflect these values throughout your employment with the Trust.
The post holder will be:
Caring - we put patients first
Ambitious - we innovate and strive for excellence
Inclusive - we respect each other and work collaboratively
Our values and behaviours framework|describes what it means for every one of us in the Trust to put our values into action.
Job description
Job responsibilities
1. Job Summary
The post will be jointly supervised between Dr Anand Shah and Dr Aran Singanayagam. This is a 18 month post funded by an industry collaboration to identify the molecular pathways relevant to disease pathophysiology in the chronic respiratory condition bronchiectasis. The post will use existing ethically approved research projects to obtain clinical samples including upper and lower airway samples from individuals with chronic respiratory disease with a focus on bronchiectasis. A key aspect of the project will be to expand bronchial epithelial samples to be used within multiple analysis techniques and/or assays. In particular, the cultured cells will be used to create different models of disease such air-liquid interface cultures which can be used to study responses both before and after administration of different stimuli (e.g. pathogens or inflammatory ligands) and/or candidate molecules
We are aiming to recruit an enthusiastic, dynamic, and motivated postdoctoral research associate with an interest in host-pathogen interactions, who wishes to expand their research portfolio. You will join an exciting multidisciplinary group with expertise in immunology and molecular microbiology. The post holder will be required to work both individually and as a team and may be required to teach more junior members of the laboratory. You should integrate with the group with a cooperative, enthusiastic and flexible approach.
Essential Requirements:
PhD in immunology or equivalent vocational qualification
Work independently and be competent in general lab techniques, including cell culture, qPCR, ELISA, WB, bioinformatics and data analysis.
Desirable Requirements:
Prior experience in epithelial cell culture including air-liquid interface and/or pulmonary organoid models
Prior experience in analysis of large sequencing datasets (bulk RNA-seq) with associated competence in using R or similar analysis packages.
2. Key Relationships
The postholder will be integrated into the research group led by Dr Anand Shah and Dr Aran Singanayagam with a clinical translational research role across the Royal Brompton hospital and the Centre of Bacterial Resistance Biology, Imperial College London.
Selected papers from the Shah/Singanayagam lab
Almond M, Farne H, K, Jackson MM, Jha A, Katsoulis O (et al)Johnston SL, Singanayagam A. Obesity dysregulates the pulmonary antiviral immune response. Nature Communications 2023. 14: 6607.
George PM, Reed A, Desai S, Devaraj A, Faiez TS, (et al)Shah A, Singanayagam A. A persistent neutrophil-associated immune signature characterises post-COVID19 pulmonary sequelae. Science Translational Medicine. 2022; 14: 671
Singanayagam A, Foottit J, Marcyzynski M, Radicioni G, Cross MT et al. Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease. J Clin Invest 2022; 132: e120901.
Kamal F, Kumar S, Edwards MR, Veselkov K, Belluomo I, (et al.).Singanayagam A, Hanna GB*. Virus-induced volatile organic compounds are detectable in exhaled breath during pulmonary infection. Am J Respir Crit Care Med 2021. 204: 1075-85.
Finney L, Glanville N, Farne H, Aniscenko J, Fenwick P, (et al.)Johnston SL, Singanayagam A. Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon. J Allerg Clin Immunol 2021; 147: 510-19.
3. Duties and Responsibilities
- To take initiatives in the planning of research
- To direct the work of small research teams
- To conduct data analysis
- To write reports for submission to research sponsors
- To present findings to colleagues and at conferences
- To submit publications to refereed journals
- To provide guidance to PhD Students
To actively participate in the research programme of the Group
To participate in Group research meetings and internal seminars
To contribute to the smooth running of the Groups laboratories and, facilities with other scientists, clinicians, technicians and students within the laboratories
Assist in the supervision of undergraduate and postgraduate research students and research assistants as required
Any other duties as may be deemed reasonable by Head of group as well as Head of Division/Department/Section
Job description
Job responsibilities
1. Job Summary
The post will be jointly supervised between Dr Anand Shah and Dr Aran Singanayagam. This is a 18 month post funded by an industry collaboration to identify the molecular pathways relevant to disease pathophysiology in the chronic respiratory condition bronchiectasis. The post will use existing ethically approved research projects to obtain clinical samples including upper and lower airway samples from individuals with chronic respiratory disease with a focus on bronchiectasis. A key aspect of the project will be to expand bronchial epithelial samples to be used within multiple analysis techniques and/or assays. In particular, the cultured cells will be used to create different models of disease such air-liquid interface cultures which can be used to study responses both before and after administration of different stimuli (e.g. pathogens or inflammatory ligands) and/or candidate molecules
We are aiming to recruit an enthusiastic, dynamic, and motivated postdoctoral research associate with an interest in host-pathogen interactions, who wishes to expand their research portfolio. You will join an exciting multidisciplinary group with expertise in immunology and molecular microbiology. The post holder will be required to work both individually and as a team and may be required to teach more junior members of the laboratory. You should integrate with the group with a cooperative, enthusiastic and flexible approach.
Essential Requirements:
PhD in immunology or equivalent vocational qualification
Work independently and be competent in general lab techniques, including cell culture, qPCR, ELISA, WB, bioinformatics and data analysis.
Desirable Requirements:
Prior experience in epithelial cell culture including air-liquid interface and/or pulmonary organoid models
Prior experience in analysis of large sequencing datasets (bulk RNA-seq) with associated competence in using R or similar analysis packages.
2. Key Relationships
The postholder will be integrated into the research group led by Dr Anand Shah and Dr Aran Singanayagam with a clinical translational research role across the Royal Brompton hospital and the Centre of Bacterial Resistance Biology, Imperial College London.
Selected papers from the Shah/Singanayagam lab
Almond M, Farne H, K, Jackson MM, Jha A, Katsoulis O (et al)Johnston SL, Singanayagam A. Obesity dysregulates the pulmonary antiviral immune response. Nature Communications 2023. 14: 6607.
George PM, Reed A, Desai S, Devaraj A, Faiez TS, (et al)Shah A, Singanayagam A. A persistent neutrophil-associated immune signature characterises post-COVID19 pulmonary sequelae. Science Translational Medicine. 2022; 14: 671
Singanayagam A, Foottit J, Marcyzynski M, Radicioni G, Cross MT et al. Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease. J Clin Invest 2022; 132: e120901.
Kamal F, Kumar S, Edwards MR, Veselkov K, Belluomo I, (et al.).Singanayagam A, Hanna GB*. Virus-induced volatile organic compounds are detectable in exhaled breath during pulmonary infection. Am J Respir Crit Care Med 2021. 204: 1075-85.
Finney L, Glanville N, Farne H, Aniscenko J, Fenwick P, (et al.)Johnston SL, Singanayagam A. Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon. J Allerg Clin Immunol 2021; 147: 510-19.
3. Duties and Responsibilities
- To take initiatives in the planning of research
- To direct the work of small research teams
- To conduct data analysis
- To write reports for submission to research sponsors
- To present findings to colleagues and at conferences
- To submit publications to refereed journals
- To provide guidance to PhD Students
To actively participate in the research programme of the Group
To participate in Group research meetings and internal seminars
To contribute to the smooth running of the Groups laboratories and, facilities with other scientists, clinicians, technicians and students within the laboratories
Assist in the supervision of undergraduate and postgraduate research students and research assistants as required
Any other duties as may be deemed reasonable by Head of group as well as Head of Division/Department/Section
Person Specification
Qualifications/ Education
Essential
- A primary degree in a health or biology related subject
- PhD in biology or related subject
- Work independently and be competent in general lab techniques, including cell culture, qPCR, ELISA, WB, bioinformatics and data analysis.
Essential
- Ability to work as part of a team as well as on own initiative
Essential
- Work independently and be competent in general lab techniques, including cell culture, qPCR, ELISA, WB, bioinformatics and data analysis
- Prior experience in epithelial cell culture including air-liquid interface and/or pulmonary organoid models
- Prior experience in analysis of large sequencing datasets (bulk RNA-seq) with associated competence in using R or similar analysis packages
Qualifications/ Education
Essential
- A primary degree in a health or biology related subject
- PhD in biology or related subject
- Work independently and be competent in general lab techniques, including cell culture, qPCR, ELISA, WB, bioinformatics and data analysis.
Essential
- Ability to work as part of a team as well as on own initiative
Essential
- Work independently and be competent in general lab techniques, including cell culture, qPCR, ELISA, WB, bioinformatics and data analysis
- Prior experience in epithelial cell culture including air-liquid interface and/or pulmonary organoid models
- Prior experience in analysis of large sequencing datasets (bulk RNA-seq) with associated competence in using R or similar analysis packages
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Certificate of Sponsorship
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the .
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. .
Additional information
Disclosure and Barring Service Check
This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Certificate of Sponsorship
Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the .
From 6 April 2017, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. .
Employer details
Employer name
Guy's and St Thomas' NHS Foundation Trust
Address
Royal Brompton Hospital and Centre of Bacterial Resistance Biology, Imperial College London
London
SW3 6NP
Employer's website
'/%3e%3cpath%20d='M101.744%2012.4726L102.894%2016.1947L99.0021%2013.2201L101.744%2012.4726ZM105.3%208.40937H100.488L99.0026%203.59473L97.5116%208.41047L92.7%208.40385L96.5965%2011.3834L95.1055%2016.1942L99.0021%2013.2196L101.408%2011.3834L105.3%208.40992V8.40937Z'%20fill='white'/%3e%3cdefs%3e%3clinearGradient%20id='paint0_linear_5593_1381'%20x1='90'%20y1='9.44471'%20x2='99'%20y2='9.44471'%20gradientUnits='userSpaceOnUse'%3e%3cstop%20stop-color='%2300AD70'/%3e%3cstop%20offset='0.998594'%20stop-color='%2300B67A'/%3e%3cstop%20offset='1'%20stop-color='%23DCDCE6'/%3e%3c/linearGradient%3e%3c/defs%3e%3c/svg%3e){kind=small}
Land a better
job faster
job faster
Follow us
