Research Associate - Cytoneme Signalling in Development

University of Manchester; Manchester; Hybrid; GBP 38,000 - 52,000; Full time

Benefits offered by this job

Generous employer contribution pension

29 days annual leave plus bankholidays

Ride to work and EV car scheme

Job summary

The Manning Lab at the University of Manchester invites applications for a three-year Wellcome-funded post to study how cytonemes transmit Notch signals during development. This post involves cell culture, live imaging, mouse embryo work, and correlative light and electron microscopy, with a strong emphasis on collaboration across groups.

You will explore signal transmission during development, develop quantitative imaging workflows, and manage your own project while communicating findings at

Qualifications

• Hold a PhD or due to complete PhD within 6 months in developmental or cell biology
• Strong knowledge of developmental biology or cell biology
• Significant experience in live‑cell or live‑tissue fluorescence imaging and the quantitative analysis of microscopy data.
• Experience in cell and molecular biology techniques such as CRISPR gene editing, immunofluorescence, qPCR, PCR, western blotting
• Willingness to work with mouse embryos and to complete all required training and competency assessment.

Responsibilities

• Undertaking a programme of research to determine how cytonemes mediate signalling during developmental patterning and cell‑fate decisions.
• Developing robust image‑analysis and quantitative workflows to extract reproducible biological measurements from microscopy data.
• Managing your own research activity, identifying technical challenges and working with collaborators to develop practical solutions.
• Communicating findings through project meetings, conference presentations and high-quality research publications.

Skills

Live-cell imaging

Fluorescence imaging

Quantitative data analysis

Collaborative research

Communication of findings

Education

PhD in developmental or cell biology

Tools

CRISPR gene editing

Immunofluorescence

qPCR

PCR

Western blotting

Job description

The Manning Lab at the University of Manchester invites applications for a three-year Wellcome-funded post to study how cytonemes transmit Notch signals during development. This post involves cell culture, live imaging, mouse embryo work, and correlative light and electron microscopy, with a strong emphasis on collaboration across groups.

You will explore signal transmission during development, develop quantitative imaging workflows, and manage your own project while communicating findings at