Research Associate

University of Sheffield; Sheffield; On-site; GBP 30,000 - 40,000; Full time

Job summary

A prestigious educational institution in Sheffield is seeking a highly motivated Research Associate for a 3-year project in the field of Translational Neuro-Oncology. The successful candidate will investigate therapeutic resistance in glioblastomas, design experiments, and collaborate on scientific research. A PhD in molecular or cell biology is required, alongside strong skills in human cell culture and molecular techniques. Excellent communication abilities are essential.

Qualifications

• Experience in human cell culture, preferably stem cell culture.
• Expertise in cancer cell biology and DNA damage response pathways is advantageous.
• Excellent interpersonal skills expected.

Responsibilities

• Design and execute experiments for mechanistic interrogation.
• Maintain detailed records and prepare reports.
• Contribute to scientific manuscripts and present at lab meetings.
• Supervise students and collaborate within the research team.

Skills

Human cell culture

Western blotting

Immunohistochemistry

Cell survival assays

Excellent communication skills

Education

PhD in molecular or cell biology

Job description

University of Sheffield

Applications are invited for the post of Research Associate to join Sheffield’s Translational Neuro-Oncology Research Group led by Prof. Spencer Collis (Science), Mr. Ola Rominiyi (Translational), and Mr. Yahia Al-Tamimi (Clinical) based within the Division of Clinical Medicine at the University of Sheffield’s Medical School.

The overarching goal of the Sheffield Translational Neuro-Oncology team is to identify and develop new targets and treatment regimens to improve the clinical management of high-grade glioblastomas and related brain tumours. More information on the Collis and Rominiyi laboratories can be found here: Spencer Collis Laboratory and Ola Rominiyi Laboratory.

We seek a highly motivated, practically skilled, well-organised, and semi-independent individual to work on a 3-year YCR-funded project. The project involves mechanistic interrogation of intra/inter-tumoural heterogeneity within the DNA Damage Response (DDR) and its impact on therapeutic resistance. The research will focus on spatially-mediated molecular divergence in response to chemo/radiotherapy and DDR inhibitors within a cohort of matched glioma stem cell (GSC) models from the Sheffield Living Biobank.

The successful candidate will be a practically skilled, well-organised, flexible, and committed Postdoctoral Researcher. Responsibilities include designing, executing, and evaluating experiments; maintaining detailed records; preparing reports; contributing to scientific manuscripts; attending and presenting at lab meetings; supervising students; and collaborating within the research team.

Requirements include a PhD (or near completion) in molecular or cell biology, experience in human cell culture (preferably stem cell culture), western blotting, immunohistochemistry, and cell survival assays (preferably clonogenic assays). Expertise in cancer cell biology, stem cell biology, and DNA damage response pathways is advantageous but not essential. Excellent communication and interpersonal skills are expected.

The Division of Clinical Medicine aims to translate scientific discoveries into clinical advances. More information about the department can be found here: Division of Clinical Medicine. The Medical School has received a Silver Athena SWAN award for promoting gender equality: Athena SWAN.