Research Associate

Autolus Therapeutics; London; On-site; GBP 28,000 - 39,000; Full time

Job summary

A leading biotech company in London is seeking a motivated Research Associate to join their Binder Discovery Group. This role involves generating and characterising antibody-based proteins to advance CAR T cell therapy for cancer treatment. Applicants should have a strong lab background in immune-oncology strategies, creativity, and the ability to work within a multidisciplinary team to drive projects forward toward clinical applications.

Qualifications

• Strong background in lab-based research with a focus on antibody-based proteins.
• Ability to execute experiments independently and interpret complex datasets.
• Experience working in a multidisciplinary research environment is beneficial.

Responsibilities

• Conduct mammalian cell culture and molecular biology experiments.
• Characterise antibody and CAR T cell performance using various protein analysis techniques.
• Document findings clearly and present data effectively to teams.

Skills

Mammalian cell culture techniques

Molecular biology techniques

Data interpretation and analysis

Education

Background in immune-oncology

Job description

Role Summary

We are looking for a motivated Research Associate level scientist to join a multidisciplinary group of researchers within the Binder Discovery Group. This role will focus generation and characterisation of new antibody-based proteins targeting a variety of cancer antigens, TME factors and cell engineering targets to develop and improve CAR T cell therapy.

Successful candidates will need creativity, curiosity and a strong scientific rationale to develop and assess novel antibodies and cell targeting entities as well as help drive projects towards the clinic. A strong background of lab-based research showing independence as well as a solid understanding of immune-oncology therapeutic strategies will be a significant advantage.

This work will be performed in close collaboration with the wider Autolus R&D teams and successful applicants will work within a wider context of translational and cell manufacturing divisions. Rapid translation to clinical testing is a key motivation of the company. This is a unique opportunity to work at the forefront of immunotherapy in rapidly moving and truly multi-disciplinary field.

Key Responsibilities

• Mammalian cell culture techniques including aseptic work with multiple different cell lines and culture types.
• Molecular biology techniques including PCR, cloning, DNA analysis, modelling of cloning using appropriate software (snapgene etc).
• Characterisation of antibody and CAR T cell performance including;
• Protein analyses techniques; Purification, ELISA, Biacore SPR, SEC chromatography, DSF etc.
• Cell analysis techniques; Cell culture, flow cytometry, Incucyte, cytokine assays, cytotoxicity assays.
• Clear and concise documentation of laboratory findings in electronic lab notebook.
• Plan and execute experiments with conflicting timelines.
• Interpret complex data sets using statistics packages and present conclusions concisely including in presentations to R&D teams and VP/CSO.
• Any other duties as required following consultation with the post holder.

Seniority level

• Seniority level

  Entry level

Employment type

• Employment type

  Contract

Job function

• Job function

  Science

• Industries

  Medical and Diagnostic Laboratories

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