Research Assistant in Single Cell Genomics (Imperial)

British Neuroscience Association; England; Hybrid; GBP 43,000 - 47,000; Full time

Job summary

Une association de neuroscience au Royaume-Uni recherche un Assistant de Recherche en Génomique à Cellule Unique pour travailler sur des méthodes novatrices afin de mieux comprendre les mécanismes neurodégénératifs. Le candidat idéal aura une expérience en biologie moléculaire et sera motivé à relever des défis scientifiques dans un environnement de collaboration multidisciplinaire.

Qualifications

• Expérience avec des méthodes de biologie moléculaire et génomique cellulaire.
• Capacité à travailler en équipe multidisciplinaire.
• Approche organisée et méthodique au travail.

Responsibilities

• Développer de nouvelles méthodes pour la génomique à cellule unique.
• Tester et mettre en œuvre des protocoles novateurs.
• Collaborer avec une équipe de recherche multidisciplinaire.

Skills

Méthodes de biologie cellulaire

Collaboratif

Approche méthodique

Tools

Plateformes microfluidiques

Job description

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• Research Assistant in Single Cell Genomics (Imperial)

Research Assistant in Single Cell Genomics (Imperial)

Vacancy Reference Number MED05199 Closing Date 2 Jul 2025 Salary £43,003 - £46,297 per annum Address UK Dementia Research Institute, White City Campus - Hybrid Duration Full time - Fixed term

Dementia is the biggest health challenge of our century.

To date there is no way to prevent it or even slow its progression, and there is an urgent need to fill the knowledge gap in our basic understanding of the diseases that cause it.

The UK Dementia Research Institute (UK DRI) is the biggest UK initiative driving forward research to fill this gap.

The UK DRI at Imperial brings together researchers from diverse backgrounds with fresh perspectives, drawing on the university’s unique strengths, resources and focus on science, engineering, medicine and business. The team recognises that the challenges of dementia demand new concepts, new approaches and a diverse range of new research tools and directions. Their holistic approach views the ageing brain in the context of the ageing body, not in isolation.

What you would be doing

We are developing new methods for profiling the binding of transcription factors to DNA. We need these methods to work at single cell resolution which is requiring us to push the limits of existing microfluidics capabilities. You will be responsible for developing, testing and implementing novel protocols towards this goal. The Neurogenomics Lab is exploiting these technologies to enable genome function to be understood in disease relevant cell types. This is being done with a view towards commercialisation so would suit a highly motivated tech minded scientist with an engineering approach to molecular biology.

Working in state-of-the-art laboratories on Imperial’s newest campus for innovation in the heart of the west London tech corridor, the research group of Dr Nathan Skene in the UK DRI at Imperial seeks to identify regulatory mechanisms which cause neurodegenerative disorders, along with the cell types in which they act, and determine whether inhibition or activation of the pathway is associated with increased disease risk. Dr Skene’s research focuses on answering simple questions about brain diseases, through the analysis of epigenomic and genetic datasets. A major question of our group is identifying which cell types carry the most genetic load for brain disorders, by linking GWAS data to epigenomic data obtained using single cell methods. This research area is evolving rapidly. You will be given opportunities to train in new methods, develop new competencies relevant to the specific aims set and address major questions of importance for Alzheimer’s disease and related neurodegenerative conditions.

What we are looking for

• Development of novel methods for single cell genomics, using customisable microfluidic platforms
• Experience with general molecular biology and cellular genomics methods
• Work collaboratively as part of a multidisciplinary research team
• Demonstrate an aptitude for an organised, methodical approach to your work

If you require any further details on the role please contact: Dr Nathan Skene [e-mail]