Research Assistant in Single Cell Genomics

Imperial College London; London; On-site; GBP 30,000 - 38,000; Full time

Job summary

Imperial College London invites applications for a fully funded Research Assistant position in Single Cell Genomics, tailored for a tech-minded scientist. This role combines cutting-edge technologies and contributions to understanding neurodegeneration, with a focus on developing new genomic profiling methods.

Benefits

Access to cutting-edge technologies

Participation in UK DRI events

Opportunities for career development

39 days off annually

Generous pension scheme

Qualifications

• Experience in single cell genomics and molecular biology techniques required.
• Tech-minded scientist with an engineering approach to molecular biology.
• Ability to work collaboratively in a multidisciplinary team.

Responsibilities

• Develop novel methods for single cell genomics using microfluidic platforms.
• Analyze epigenomic and genetic datasets.
• Contribute to research on neurodegenerative disorders.

Skills

Molecular biology

Cellular genomics techniques

Microfluidics

Collaborative work

Organized approach

Education

PhD in relevant field

Job description

Applications are invited for a fully funded Research Assistant position in Single Cell Genomics at Imperial College London, within the laboratory of Dr. Nathan Skene, Department of Brain Sciences.

Today, over 1 million people in the UK are living with dementia and related neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases. The impact of these incurable and progressive conditions on individuals and their families is devastating. The cost to the economy and public services is large and growing as the UK population ages.

The UK Dementia Research Institute is a globally leading multidisciplinary research institute with over 900 staff investigating neurodegenerative disorders causing dementia. The institute aims to understand neurodegeneration better and develop interventions for diagnosis, treatment, and prevention.

We are developing new methods for profiling transcription factor binding to DNA at single cell resolution, requiring pushing microfluidics capabilities. You will develop, test, and implement novel protocols towards this goal. The Neurogenomics Lab exploits these technologies to understand genome function in disease-relevant cell types, with an eye towards commercialisation. This role suits a motivated, tech-minded scientist with an engineering approach to molecular biology.

Based on Imperial’s newest campus for innovation in West London, Dr. Skene’s group seeks to identify regulatory mechanisms causing neurodegenerative disorders, relevant cell types, and pathways associated with disease risk. The research focuses on analyzing epigenomic and genetic datasets, linking GWAS data to epigenomic data from single-cell methods. The field is rapidly evolving, offering opportunities to train in new methods and contribute to major questions in Alzheimer’s and related diseases.

• Development of novel methods for single cell genomics using customizable microfluidic platforms
• Experience with molecular biology and cellular genomics techniques
• Collaborative work within a multidisciplinary research team
• Organized, methodical approach to work

The role is part of the UK Dementia Research Institute and the Department of Brain Sciences at Imperial College London. Research Assistants benefit from:

• Access to cutting-edge technologies
• Participation in UK DRI events like the annual ‘Connectome’ scientific meeting
• A network of computational and wet lab researchers
• Opportunities for career development at a leading institution
• Competitive salary and benefits, including 39 days off annually and a generous pension scheme