Protein Scientist - Phage Display (Scientist/Senior Scientist)

ZipRecruiter; Oxford; On-site; GBP 40,000 - 60,000; Full time

Job summary

A leading biotech firm in the UK seeks a candidate for their Protein Science team to develop high affinity bispecific TCR molecules for clinical development. The ideal applicant holds a PhD and has extensive experience in affinity maturation and molecular biology techniques. Key responsibilities include collaboration with various teams and experimental design. A strong organizational skill set and the ability to thrive in a team environment are essential.

Qualifications

• PhD in a relevant biological subject with relevant experience.
• Experience with affinity maturation of TCRs or antibodies.
• Familiarity with a range of molecular biology techniques.

Responsibilities

• Develop soluble TCR-based therapeutics for clinical development.
• Collaborate with various teams for optimization of soluble TCRs.
• Design and conduct experiments to meet scientific timelines.

Skills

Affinity maturation of TCRs or antibodies using phage display

Molecular biology techniques

Strong organization and multitasking skills

Team collaboration

Strong communication skills

Education

PhD in relevant biological subject

Job description

Job Description

Role Summary

In this role you will be a core part of the Protein Science team, working collaboratively with protein scientists to develop soluble high affinity bispecific TCR molecules suitable for later stage clinical development.

Key Deliverables

• Affinity enhance and produce soluble TCR-based therapeutics for clinical development using cutting-edge molecular biology techniques.
• Work collaboratively with the Cell Biology and Engineering teams to guide optimisation and development of soluble TCRs.
• Effectively design and conduct experimental work to align with Company priorities and meet scientific timelines, report results succinctly and effectively.
• Presenting work to your department, project team and the company leadership team

Experience/Qualifications

• A PhD in a relevant biological subject with relevant experience
• (Required) Experience with affinity maturation of TCRs or antibodies using phage display
• (Required) Experienced with a broad range of molecular biology techniques including the design and modification of expression vectors and a range of cloning strategies and techniques
• (Desired) Experience in the design and optimisation of purification protocols to produce high quality proteins and in biochemical analyses of protein properties
• (Desired) Experienced in mammalian expression of proteins (CHO, HEK293 cells)
• (Desired) Experience in developing and executing protein expression, and purification using various FPLC based techniques
• (Desired) Experience in analyses of protein properties using SPR and BLI or other protein binding assay techniques
• (Desired) Direct hands-on laboratory experience in developing high affinity antibodies or soluble TCR molecules
• (Required) Strong organisation and multitasking skills
• Inclusive, collaborative, and thrives in a team environment with a flexible approach to working.
• Strong communication skills with the confidence to challenge appropriately.
• Demonstrable problem-solving ability and creative thinker