Process Engineer, Drug Substance Development

GSK; Letchworth; On-site; GBP 52,000 - 80,000; Full time

Job summary

GSK is seeking a DSD-based engineer to develop and deliver state-of-the-art processes supporting medicines development. The role is rooted in R&D laboratories, collaborating with chemists and material scientists to build robust scale-up strategies for future manufacturing.

You will integrate digital data, analytics, and engineering principles to drive process development and technology transfer for clinical to commercial manufacturing. Relocation plans are described in the posting.

Qualifications

• BSc/BEng/Masters or PhD in Process/Chemical Engineering.
• Experience in pharmaceutical plant or lab environment.

Responsibilities

• Design and conduct scale-up/down experiments across chemical engineering unit operations.
• Optimize engineering solutions and de-risk scale-up processes.
• Analyse results and present conclusions at internal R&D meetings.
• Contribute to technology-transfer activities with manufacturing partners.
• Use digital data and analytics to inform process-development decisions.
• Ensure compliance with Data Integrity, cGMP and safety in the lab.

Skills

Process Engineering

Chemical Engineering

Laboratory experience

Education

BSc/BEng/Masters / PhD in Process/Chemical Engineering

Tools

DynoChem

Process Analytical Technology (PAT)

Job description

For candidates seeking to be located at our Stevenage site, this role will temporarily be based at Stevenage. However, the Company plans to relocate its offices to Ware. The location of this role will therefore subsequently change to Ware in accordance with timelines to be set by the Company. The relocation is currently proposed to take effect by early 2029.

As a member of DSD, you will apply your engineering knowledge to develop and deploy state-of-the‑art processes and technologies that support the development and delivery of GSK medicines.

This is a practical role based in R&D laboratories, where you will work alongside chemists and material scientists to build the process understanding needed for successful scale-up and commercial industrialisation of future GSK manufacturing processes.

You will combine digital, data and analytics (DDA) information from laboratory studies with engineering principles, process simulation and modelling to develop robust, scalable and sustainable pharmaceutical manufacturing processes. As processes transfer to pilot-plant facilities for clinical-trial delivery or to manufacturing facilities for commercialisation, you will provide global support as the engineering technical expert.

The work will focus primarily on chemistry-based small molecules and oligonucleotides, with potential involvement in biochemistry-based large molecules, vaccines and antibody‑drug conjugates.

Responsibilities

• Design and conduct scale‑up and scale‑down experiments across chemical engineering unit operations, building process understanding within fast‑paced project timelines.
• Think creatively to optimise engineering solutions and de‑risk scale‑up processes.
• Analyse experimental results and communicate conclusions and recommendations clearly at internal R&D meetings.
• Contribute to technology‑transfer activities with GSK manufacturing partners, providing engineering input appropriate to the project stage.
• Use digital data and analytics alongside engineering expertise to predict and inform process‑development decisions and manage scale‑up risk.
• Author or contribute to internal documentation relevant to the role.
• Comply with applicable Data Integrity, Quality, cGMP (current Good Manufacturing Practice) and regulatory requirements in all aspects of work and fully embrace all aspects of safety when working in the laboratory.

Required Skills

• BSc/BEng/Masters / PhD (or equivalent) in Process/Chemical Engineering.
• Experience working in a plant and/or direct laboratory experience in the pharmaceutical industry, or related sector.

Preferred Qualifications & Skills

• Practical familiarity with process simulation/modelling techniques such as DynoChem and similar software.
• Experience collecting and interpreting digital process data, including through Process Analytical Technology (PAT), and using analytics to support timely decision‑making.
• Experience working effectively in a cross‑functional scientific or engineering team.
• Asset Life Cycle Management, Data Integrity, Digital Fluency, GxP Regulations, Lean Management, Manufacturing Technologies, Pharmaceutical Manufacturing, Problem Solving, Risk Awareness, Standards Compliance.

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive.

We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases - to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.