Process Development Scientist, Downstream - Oxford

ZipRecruiter; Oxford; On-site; GBP 30,000 - 50,000; Full time

Job summary

A pioneering biotechnology company in Oxford seeks a Process Development Scientist to support downstream process development. The successful candidate will design experiments, manage schedules, and ensure compliance with GMP requirements while contributing to breakthrough therapies. Ideal applicants will have a background in molecular biology or biochemistry and experience in laboratory settings.

Qualifications

• Essential experience in microbial or mammalian expression and biochemistry.
• Skilled in designing experiments and interpreting results.
• Ability to maintain accurate records and communicate effectively.

Responsibilities

• Conduct experiments, interpret results, and respond accordingly.
• Plan and prioritize experiments while alerting managers to risks.
• Maintain and expand technical knowledge through training.

Skills

Aseptic techniques

Microbial manipulations

Recombinant protein expression

Purification

SDS-PAGE

General lab software

Laboratory equipment operation

Education

BSc in protein or biochemical engineering

MSc in biochemistry

PhD in microbiology

PhD in molecular biology

Job description

Job Description

Process Development Scientist, Downstream - Oxford

Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company dedicated to developing and commercializing transformative medicines to address unmet patient needs in oncology, infectious diseases, and autoimmune diseases. Our R&D leaders are recognized globally as some of the most successful drug developers in the biotech industry. We foster an environment that encourages collaboration, innovation, and the pursuit of big questions.

We focus on delivering first-in-class biological therapies, including our highly innovative soluble TCR platform. Our ImmTAX molecules represent a new class of precision-engineered drugs that harness the immune system to treat diseases with high unmet medical needs.

At Immunocore, we value the contributions of each individual and embrace our core values: Science, Trust, Respect, Integrity, and Entrepreneurship (STRIDE). These values drive our mission and create a thriving, inclusive workplace where ideas flourish.

We are committed to developing breakthrough therapies that improve patients' lives and support our team in these efforts. Immunocore is an equal opportunity employer, dedicated to fostering an inclusive environment where everyone feels valued and respected. We encourage applications from individuals of all backgrounds, regardless of race, gender, sexual orientation, gender identity, age, disability, or any other protected characteristic.

Role Overview:

This role involves designing and conducting experimental investigations to support downstream process development of emerging drug candidates, including the establishment of manufacturing and clinical production processes. Key responsibilities include protein purification, implementing chromatography and separation techniques, and analytical assessments of purity (e.g., SDS-PAGE, HPLC). The candidate must work independently and collaboratively under tight deadlines, maintaining accurate records and communicating effectively with external partners for GMP manufacturing and regulatory compliance.

Key Responsibilities:

1. Conduct experiments, interpret results, and respond accordingly.
2. Follow experimental protocols and prepare reports.
3. Plan and prioritize experiments, alerting managers to risks or deviations.
4. Maintain and expand technical knowledge through self-study and training.
5. Accurately document all work in laboratory notebooks.
6. Operate laboratory equipment safely and report faults promptly.
7. Ensure compliance with health and safety policies.

Specific Responsibilities:

1. Run pre-established investigation lines independently, seeking guidance when needed.
2. Manage experiment schedules and communicate risks or delays.
3. Develop technical knowledge and share skills with colleagues.
4. Keep laboratory records up-to-date and accurate.
5. Attend training on technical equipment and maintain assigned instruments.
6. Present research findings internally and in reports.
7. Comply with health and safety requirements and attend relevant training.

Experience and Knowledge (Essential):

• Experience in microbial or mammalian expression, biochemistry, molecular biology, analytical, or biopharmaceutical labs.
• Skills in aseptic techniques, microbial manipulations, recombinant protein expression, purification, SDS-PAGE, and general lab software.
• Ability to design experiments, interpret results, and work in a team.

Desirable Skills:

• Molecular biology, biophysical protein characterization, protein-protein interaction analysis (Biacore, Octet).
• Troubleshooting, mammalian expression, knowledge of cGMP, DoE, lab management, and experience presenting scientific data.

Education & Qualifications:

• BSc, MSc, or PhD in protein or biochemical engineering, biochemistry, microbiology, molecular biology, or related fields.
• Relevant industrial or academic experience is a plus.