Principal Scientist PK/PD

UCB S.A.; Princes Risborough; On-site; GBP 90,000 - 120,000; Full time

Job summary

UCB is seeking a Principal Scientist, Non-Clinical PKPD, to join the Clinical Development Sciences Group at our R&D site in Slough, UK, and Windlesham, Surrey. You will shape the quantitative PKPD strategy across target identification to lifecycle management, collaborating with Bioanalysis, Clinical Pharmacology and Translational Medicine.

This role requires a PhD with strong PKPD expertise, leadership, and experience building complex models to inform decision-making in a matrix environment,

Qualifications

• PhD in pharmacology, pharmaceutical sciences, pharmacokinetics/pharmacodynamics, systems biology or related field.
• Strong understanding of pharmacology and drug mechanisms.
• Expertise in PKPD methods and concepts for drug discovery and development.
• Experience leading non-clinical PKPD strategies from discovery to clinic.
• Proven leadership in a matrix environment with diverse internal stakeholders.
• Experience using modelling and simulation packages.

Responsibilities

• Develop and drive the nonclinical PKPD strategy for projects.
• Translate in vitro and in vivo data to predict efficacy and safety in patients.
• Build PKPD models to test hypotheses and inform decisions.
• Represent PKPD interests internally and externally to enhance scientific reputation.
• Lead multifunctional collaborations to advance drug candidates.

Skills

PKPD modelling

Pharmacology knowledge

Leadership in matrix environments

Collaborative cross-functional work

Education

PhD in pharmacology/pharmaceutical sciences

Tools

Phoenix

Berkeley Madonna

R

Monolix

Job description

department, is responsible for providing strategy and support in bioanalysis, immunogenicity, safety, pathology, and regulatory activities. Work with external partners, academic institutions, CROs and consultants as required.

What you’ll do

Develop and drive the nonclinical PKPD strategy for projects. Communicating effectively ensuring implementation in projects.

Ensure translation from in vitro data and in vivo nonclinical studies to prediction of efficacy and safety in patients. Initiate and engage in multifunctional collaborations to facilitate the advancement of drug candidates and build a thorough knowledge of drug pharmacology and PKPD, leading to quantitative translation to the clinic.

Build PKPD models of sufficient complexity to allow hypothesis testing and inform decision-making. Represent the interests of QCP internally and externally in matters relevant to mechanistic PKPD and contribute to enhancing the scientific reputation of Non-Clinical PKPD, QCP and UCB.

Education, experience and skills

PhD in relevant discipline (pharmacology, pharmaceutical sciences, pharmacokinetics/pharmacodynamics, system biology or related fields).

Good understanding of pharmacology and pharmacologic processes related to disease and drug mechanisms.

Expertise and proven application of PKPD methods and concepts in support of drug discovery and development; systems modelling experience would be advantageous.

Demonstrated experience in developing and executing effective non-Clinical PKPD strategies from early discovery through to clinic.

Demonstrated experience and leadership skills working within a matrix environment with a wide range of internal stakeholders including Non-Clinical Safety, Bioanalysis, Clinical Pharmacology and Translational Medicine.

Experience in using modelling and simulation packages such

About the role

We are looking for a Principal Scientist, Non-Clinical PKPD, who is innovative and agile to join us in our Clinical Development Sciences Group, based at the R&D site in Slough, UK, then Windlesham, Surrey (#####). Our goal is to use integrated quantitative approaches as an essential strategic driver from target to market to bring differentiated solutions to patients. We are driving the quantitative integrated strategy of pharmacokinetics and pharmacology (e.g. PKPD, Systems modelling and clinical pharmacology/pharmacometrics) together with DMPK activities throughout the entirety of the lifetime of projects, from target identification through to life cycle management.

Who you’ll work with

We operate and collaborate closely with colleagues in Development Sciences, which, as a, as Phoenix, Berkeley Madonna, R and Monolix.

About us

UCB is a global biopharmaceutical company, focusing on neurology and immunology. We are over 9.000 people in all four corners of the globe, inspired by patients and driven by science.

Why work with us

At UCB, we don't just complete tasks, we create value. We aren't afraid to push forward, collaborate, and innovate to make our mark for patients. We have a caring, supportive culture where everyone feels included, respected, and has equal opportunities to do your best work. We 'go beyond' to create value for our patients, and always with a human focus, whether that's on our patients, our employees, or our planet. Working for us, you will discover a place where you can grow, and have the freedom to carve your own career path to achieve your full potential.

We’ve embraced a hybrid-first approach to work, bringing teams together in local hubs to foster collaborative curiosity. Unless expressly stated in the description or precluded by the nature of the position, roles are hybrid with 40% of your time spent in the office.

UCB is an equal opportunity employer. All employment decisions will be made without regard to any characteristic protected by applicable laws.

Contact us on #####.

Job Summary

Job number: 92379

Date posted: 6-04-28

Profession: Research & Development

Employment type: Permanent