Principal Scientist – Discovery & Translational Biology

Hyper Recruitment Solutions Ltd; Cambridgeshire and Peterborough; On-site; GBP 50,000 - 90,000; Full time

Job summary

An innovative drug-development start-up is seeking a Principal Scientist in Discovery & Translational Biology. This role offers the chance to work on groundbreaking oncology therapeutics, focusing on Antibody Drug Conjugates and Bispecific Antibodies. You will lead projects, influence early drug development strategies, and collaborate with external partners to deliver pivotal proof-of-concept data. Join a dynamic team in a start-up environment where your contributions can significantly impact patient outcomes. If you are passionate about advancing oncology research, this is the opportunity for you!

Qualifications

• PhD in relevant field with experience in oncology biologics.
• Technical expertise in primary cell culture and assay development.

Responsibilities

• Develop novel oncology therapeutics and lead project strategies.
• Support portfolio expansion through target validation and studies.

Skills

Oncology Therapeutics Development

Antibody Drug Conjugates (ADCs)

Bispecific Antibodies

Laboratory Project Leadership

Cell Tissue Culture

Flow Cytometry

IHC Assay Development

Spheroid Culture

Education

PhD in Relevant Field

Job description

Principal Scientist – Discovery & Translational Biology

14564 | Permanent | Competitive | Site Based | Cambridgeshire, United Kingdom | Updated on: 02-05-2025

A fantastic opportunity has arisen for a Principal Scientist – Discovery & Translational Biology to join a high-potential drug-development start-up focused on developing new oncology therapeutics that significantly improve overall survival for patients with high unmet needs. Our client is at the cutting edge of oncology therapeutics, leveraging proprietary algorithms to identify novel protein fingerprints from a comprehensive membrane protein database.

They are establishing their own laboratory to support their ambitious growth plans and are seeking a highly motivated Principal Scientist to join their Research Group. This is an exciting opportunity for the right candidate to make a meaningful contribution across discovery and translational sciences.

KEY DUTIES AND RESPONSIBILITIES:

1. The ideal candidate will have hands-on experience in developing novel oncology therapeutics, ideally Antibody Drug Conjugates (ADCs) or Bispecific Antibodies. You should be skilled at balancing laboratory work with project leadership and have a proven track record of building successful relationships with external partners.
2. Joining a small, growing team, this dynamic role offers the opportunity to influence strategy across all aspects of early drug development.
3. You will support portfolio expansion through target validation and co-expression studies, develop workflows for hit selection and lead triage, and deliver pivotal in vivo proof-of-concept data via external partners.

ROLE REQUIREMENTS:

1. Applicants should hold a PhD in a relevant field, with significant experience in developing novel oncology biologics, ideally ADCs or Bispecific Antibodies, gained mainly within a biotech or biopharma environment.
2. Strong technical expertise in primary cell tissue culture, flow cytometry, and IHC assay development and execution is required. Experience working with spheroids is desirable.
3. You must be comfortable working independently and proactively in a start-up environment.

Hyper Recruitment Solutions Ltd (HRS) is an Equal Opportunities employer. We welcome applications from anyone who meets the role requirements. HRS exclusively supports the STEM sectors, combining recruitment expertise with scientific knowledge to help you advance your career.

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