Principal Scientist (Biochemistry/Enzymology)

Cancer Research UK (CRUK); Cambridge; On-site; GBP 50,000 - 58,000; Full time

Job summary

An established industry player is seeking a Principal Scientist to lead innovative biochemical assay development within their Drug Discovery team. This role, based in Cambridge, offers the chance to drive cutting-edge research and collaborate with industry and academic partners to advance cancer therapy development. The successful candidate will utilize their expertise in enzyme mechanisms and biochemical assays to contribute to a strategic plan aimed at revolutionizing cancer research. With a competitive salary and flexible working options, this position is perfect for a motivated scientist looking to make a significant impact in the field.

Benefits

Pension contributions

Flexible working options

Diversity and inclusion initiatives

Qualifications

• BSc, MSc, or PhD in biochemistry or in vitro pharmacology.
• Significant experience in enzyme and small molecule inhibitor mechanisms.

Responsibilities

• Design and develop biochemical assays for cancer targets.
• Characterize mechanisms of action of small molecules.
• Provide scientific leadership and strategic direction.

Skills

Enzyme mechanisms

Biochemical assays

Drug discovery

Cellular pharmacology

Scientific leadership

Education

BSc in Biochemistry

MSc in Biochemistry

PhD in Biochemistry

Job description

Principal Scientist (Biochemistry/Enzymology)

Join to apply for the Principal Scientist (Biochemistry/Enzymology) role at Cancer Research UK (CRUK).

This role offers an exciting opportunity to lead biochemical assay design, prosecution, and analysis within our Drug Discovery team, based at the Babraham Research Campus in Cambridge or the Scotland Institute in Glasgow.

About the Role

As a Principal Scientist, you will drive innovative approaches in biochemical assays, contribute to our 5-year strategic plan, and collaborate with industry and academic partners to advance cancer research and therapy development.

Responsibilities

1. Design and develop physiologically relevant biochemical assays for cancer targets.
2. Characterize mechanisms of action of small molecules and inform dose prediction and clinical efficacy.
3. Keep abreast of cutting-edge cellular pharmacology techniques and approaches.
4. Present research findings at conferences, publish papers, and participate in scientific discussions.
5. Provide scientific leadership and strategic direction within the team.

Qualifications

• A BSc, MSc, or PhD in biochemistry or in vitro pharmacology; relevant experience may substitute for educational qualifications.
• Significant experience in enzyme and small molecule inhibitor mechanisms within a drug discovery environment.
• Understanding of enzymology, biochemical assays, and detection technologies.
• Experience in assay development for various target classes.
• Proven scientific leadership and external reputation through publications and conference presentations.

Additional Information

We offer a competitive salary from £50,400 to £57,400 per annum, benefits including pension contributions, and flexible working options. We are committed to diversity and inclusion and welcome applications from all backgrounds.

To apply, please submit your CV and complete the online application form. Early applications are encouraged as the vacancy may close sooner if a suitable candidate is found.