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Principal Scientist

Skills Alliance

Oxford

On-site

GBP 55,000 - 85,000

Full time

Yesterday

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Job summary

A pioneering biotech company is seeking a Senior or Principal Scientist to drive TCR-based therapies for solid tumors. The ideal candidate will possess a PhD with experience in molecular biology and protein science, contributing to key advancements in therapeutic development within a dynamic team.

Qualifications

PhD in a relevant discipline is required.
2-3 years of industry experience in immunotherapy.
Proven experience with T cell engagers preferred.

Responsibilities

Lead validation of T cell engagers in vitro and in vivo.
Design and characterize targeted TCRs.
Manage protein expression and purification processes.

Skills

Molecular Biology

Protein Science

Cell-based Assays

In Vitro Validation

In Vivo Validation

Education

PhD in Immunology, Cell Biology, or Biochemistry

Tools

PCR

Flow Cytometry

ELISA

NGS Library Preparation

A pioneering biotech company at the forefront of cancer immunotherapy is seeking a Senior or Principal Scientist to join their dynamic team. This organization is focused on developing next-generation T-cell receptor (TCR)-based therapies to address solid tumors—areas historically difficult to treat with conventional immunotherapies.

Role Summary

The successful candidate will play a key role in driving the engineering, in vitro, and in vivo validation of TCR-based engagers. This includes hands-on work in molecular biology, protein science, and cell-based assays, as well as collaboration across multidisciplinary teams to advance therapeutic candidates toward clinical development.

Key Responsibilities

Lead in vitro and in vivo validation of TCR-based T cell engagers.
Design and characterize TCRs targeting proprietary and partnered disease indications.
Execute protein science workflows, including expression, purification, and biophysical analyses of recombinant TCRs.
Perform molecular biology tasks: cloning, mutagenesis, DNA isolation, and library prep for sequencing.
Manage cell culture work, including media preparation, cell line maintenance, and cryopreservation.
Contribute to the creation, revision, and maintenance of laboratory protocols and standard operating procedures (SOPs).

Required Qualifications

PhD in Immunology, Cell Biology, Biochemistry, or related discipline, with:
2-3 years of industry experience.
Demonstrated experience with in vitro and in vivo validation of T cell engagers, ideally through to IND-enabling studies.
Solid understanding of molecular biology techniques (e.g., cloning, PCR).
Hands-on experience with protein expression, purification, and biophysical characterization.
Experience with cell-based assays (e.g., flow cytometry, ELISA) is desirable.
Familiarity with NGS library preparation and data analysis pipelines (e.g., using R) is a plus.
Prior SOP development and documentation experience is advantageous.

Seniority level

Seniority level
Mid-Senior level

Employment type

Employment type
Full-time

Job function

Job function
Research and Science
Industries
Biotechnology Research and Pharmaceutical Manufacturing

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