Principal Laboratory Research Scientist - Human Biology Facility

The Francis Crick Institute; London; On-site; GBP 49,000 - 60,000; Full time

Job summary

A leading biomedical research institute is seeking a stem cell expert to lead reprogramming projects and support gene editing initiatives. The role involves managing projects, scientific support, and training researchers in pluripotent stem cell best practices. The successful candidate will contribute to innovative research in a dynamic environment.

Qualifications

• Extensive wet lab experience in pluripotent cell culture.
• Proven track record of scientific publication.

Responsibilities

• Providing robust scientific support to Crick researchers.
• Managing and delivering projects within the reprogramming portfolio.
• Teaching and training scientists in best practices for growing human pluripotent stem cells.

Skills

Pluripotent Stem Cell Research

Gene Editing

Cell Engineering

Tissue Culture

Education

PhD or equivalent experience

Degree in a biological subject

Job description

Location: The Francis Crick Institute, Midland Road, London

Short summary

About the role…

The Human Models Core (HMC) is an integral part of the Human Biology Facility, operated by a team of scientific and technical experts. The HMC offers a range of services and support to researchers, working closely with the Human Biology Governance Team and research groups at the Crick. The core specializes in areas including viral vectors, pluripotent stem cells, genome editing, cell engineering, primary cells, and organoids.

We are seeking a highly motivated, proactive stem cell expert with extensive knowledge in reprogramming pluripotent stem cells (PSC), differentiation, and gene editing. The candidate should also understand primary human models and their applications. The successful applicant will lead reprogramming projects, support differentiation and gene editing projects, and assist in generating human 2D and 3D models.

Responsibilities include:

1. Providing robust scientific support to Crick researchers.
2. Managing and delivering projects within the reprogramming portfolio.
3. Supporting gene editing projects in PSC.
4. Reprogramming somatic cells to pluripotency.
5. Registering reprogrammed cell lines.
6. Establishing new methodologies in the lab.
7. Developing proof-of-concept for new research directions.
8. Horizon scanning and developing specific scientific projects and platforms collaboratively within the facility.
9. Supporting research groups and the Head of Lab Operations in grant writing and publications.
10. Providing tissue culture, quality control, and technical support to research groups.
11. Teaching and training scientists in best practices for growing, characterizing, differentiating, and banking human pluripotent stem cells.

About you…

1. A degree in a biological subject with substantial postgraduate experience in pluripotent stem cell research.
2. PhD or equivalent experience.
3. Extensive wet lab experience in pluripotent cell culture.
4. Experience in reprogramming cells to pluripotency.
5. Experience in PSC model development.
6. A proven track record of scientific publication.
7. Demonstrable experience with best practices, quality control, and related assays.
8. Highly self-motivated with a proactive approach.

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About us…

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose, and treat illnesses such as cancer, heart disease, infectious diseases, and neurodegenerative conditions.

The Crick fosters collaboration, innovation, and exploration across disciplines. It is a space where bright minds pursue big ideas and discover answers to crucial scientific questions. We support researchers in a dynamic environment with state-of-the-art infrastructure, cutting-edge facilities, and a creative culture. Our open approach removes traditional boundaries, encouraging high-risk, high-reward research that benefits human health and the economy.

To apply, please click the ‘Apply’ button above.

Starting from £49,955, depending on skills and experience, with benefits.