Principal Clinical Scientist

Alignerr Corp.; Oxford; Remote; GBP 83,000 - 165,000; Part time

Job summary

Alignerr is seeking a Principal Clinical Scientist (AI Training) to apply senior clinical expertise to the development of AI systems in a fully remote, hourly-contract role. You will design protocols, audit results, and ensure regulatory compliance for AI training datasets, working asynchronously on a flexible schedule.

The role emphasizes rigorous standards and clear communication, with potential for ongoing projects and extended engagements as AI initiatives evolve.

Qualifications

• Senior-level experience designing clinical trial protocols for regulatory submissions.
• Deep expertise interpreting clinical data for agencies such as FDA/EMA or equivalents.
• Strong grounding in biostatistics or translational science.
• Rigorous standards applied to AI-generated outputs in regulatory contexts.
• Clear, precise written communication of complex clinical reasoning.

Responsibilities

• Design and review clinical trial protocols used to generate regulator-ready datasets for AI training.
• Interpret and audit clinical trial results for accuracy, consistency, and regulatory relevance.
• Evaluate AI-generated clinical analyses for scientific soundness and regulatory alignment.
• Identify gaps and weaknesses in how AI systems reason about clinical data and outcomes.
• Provide expert feedback to improve AI understanding of clinical evidence.
• Work independently and asynchronously on your own schedule.

Skills

Senior clinical trial design

Regulatory data interpretation

Biostatistics/ Translational science

Rigorous AI validation standards

Clear technical writing

Job description

Principal Clinical Scientist (AI Training)

About The Role

What if your career designing rigorous clinical trials and interpreting regulatory-grade data could directly shape how AI reasons about biomedical evidence? We're looking for a Principal Clinical Scientist to bring senior-level clinical expertise into the development of cutting-edge AI systems — ensuring the models influencing the future of medicine are built on a foundation of scientific rigor.

This is a fully remote, flexible contract role. You'll work at the intersection of clinical research and frontier AI, applying the same standards you'd bring to an FDA or EMA submission to train and evaluate the next generation of AI models.

• Organization: Alignerr
• Type: Hourly Contract
• Location: Remote
• Commitment: 10–40 hours/week

What You'll Do

• Design and review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training
• Interpret and audit clinical trial results to ensure accuracy, consistency, and regulatory relevance
• Evaluate AI-generated clinical analyses for scientific soundness and alignment with regulatory expectations
• Identify gaps, errors, and weaknesses in how AI systems reason about clinical data and outcomes
• Provide structured, expert feedback that directly improves how AI understands clinical evidence
• Work independently and asynchronously — fully on your own schedule

Who You Are

• Senior-level experience designing clinical trial protocols for regulatory submission
• Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or equivalent
• Strong grounding in clinical research methodology, biostatistics, or translational science
• Naturally rigorous — you hold AI-generated outputs to the same standards as real-world submissions
• Clear and precise written communicator who can translate complex clinical reasoning into actionable feedback
• Self-directed and reliable when working independently

Nice to Have

• Prior experience with data annotation, data quality review, or AI evaluation systems
• Background in pharmacovigilance, clinical operations, or medical writing
• Familiarity with AI tools or content evaluation workflows as an end user
• Experience working across therapeutic areas or with cross-functional research teams

Why Join Us

• Work directly on frontier AI systems shaping the future of clinical and biomedical research
• Influence how AI understands, evaluates, and communicates real-world clinical evidence
• Fully remote and flexible — work when and where it suits you
• Freelance autonomy with the structure of meaningful, high-impact work
• Collaborate with leading AI research teams and labs on problems that matter
• Potential for ongoing work and contract extension as new projects launch