Postdoctoral Scientist - Structural Studies - Dr Joe Greener - LMB 2633

MRC Laboratory of Molecular Biology (LMB); Cambridgeshire and Peterborough; On-site; GBP 42,000; Full time

Job summary

A leading research institute in Cambridge is seeking a Postdoctoral Scientist to join a multi-disciplinary team. The role involves developing molecular simulation methods to optimize protein designs, utilizing advanced coding techniques. Applicants should possess a PhD in a relevant field or be nearing completion, with desired experience in molecular dynamics or machine learning. Comprehensive benefits include 40.5 days of holiday, pension scheme, and training opportunities.

Benefits

40.5 days holiday including bank holidays

Defined benefit pension scheme

Employee discount scheme

Staff restaurant with roof terrace

Access to nursery and sports facilities

Training and development opportunities

Qualifications

• PhD in relevant subject or to be completed within 6 months.
• Experience in coding and molecular dynamics is advantageous.
• Familiarity with protein design or machine learning preferred.

Responsibilities

• Develop molecular simulation methods for protein design tasks.
• Significant coding required using Julia and addressing computational questions.
• Focus on binding flexible regions and antibody design.

Skills

Coding

Molecular Dynamics

Machine Learning

Education

PhD in a relevant subject

Tools

Julia

Molly.jl

Job description

Postdoctoral Scientist
Salary £41,344 per annum
Fixed Term – 3 years
MRC Laboratory of Molecular Biology, Cambridge, UK

We are looking for a postdoctoral scientist to join the group of Joe Greener to undertake research in computational protein design. This will involve developing molecular simulation methods to optimise sequences for a variety of design tasks. Ensemble reweighting and alchemical simulation techniques will be used to design proteins; a particular focus is binding flexible regions and antibody design, which are challenging for current machine learning approaches.

You will become an early member of a friendly, multi-disciplinary team. The project will involve significant coding using the Julia package Molly.jl on both CPU and GPU, as well as addressing relevant computational and algorithmic questions. You will become an expert in molecular dynamics methods and relevant protein design techniques. You have a PhD in a relevant subject, or are due to complete within 6 months, and have experience in coding. Previous experience with either protein design, molecular dynamics or machine learning will be an advantage.

For informal enquiries please contact Joe Greener: [e-mail]
Group web page: https://www2.mrc-lmb.cam.ac.uk/groups/greener

This is a three-year training and development position suitable for you if you have recently completed your doctoral studies, or you are looking to move into a new research discipline and/or need to further develop your research skills. Working with our world class scientists you will be working in an Institute renowned for its excellent scientific facilities and high-quality research.

The LMB has a collaborative working culture and state-of-the-art building based on the Cambridge Biomedical Campus. We have on-site parking, cycle enclosures and excellent public transport links to the site. We have a staff restaurant with roof terrace and access to a Campus nursery and sports and social facilities. You will be eligible to join our defined benefit pension scheme, a holiday entitlement of 40.5 days (including bank holidays and privilege days) and a generous employee discount scheme. We are also committed to providing training and development opportunities including support towards role-related qualifications.

The LMB is a world-class research institute within UK Research and Innovation (UKRI). UKRI is nine research councils, working together across all disciplines and sectors. More information can be found at www.ukri.org and www.mrc-lmb.cam.ac.uk.

Closing date: 13/07/2025

Final appointments will be subject to a pre-employment screening.

We actively support equality, diversity and inclusion in all our activities, processes and culture. We encourage applications from all sections of society. The LMB particularly welcomes women, minority ethnic and disabled candidates to apply for this vacancy as they are currently under-represented. We are a disability inclusive employer and encourage disabled people to apply for this role. You are very welcome to contact us for information about the application process and any adjustments you may require; [e-mail].