Postdoctoral Scientist – RNA dynamics in cancer

Findauniversity Ltd.; United Kingdom; On-site; GBP 37,000 - 45,000; Full time

Job summary

An exciting opportunity has arisen for a postdoctoral scientist to explore the intricate relationship between diet and RNA modifications in cancer metastasis. This role involves utilizing advanced xenotransplantation models and a variety of molecular profiling techniques, focusing on RNA biology. The successful candidate will collaborate within a dynamic team, contributing to groundbreaking research that could lead to significant advancements in cancer treatment. This position not only offers a chance to deepen your expertise in RNA dynamics but also access to patient samples for validation of findings. Join a forward-thinking research environment where your contributions can make a real difference.

Qualifications

• PhD in Molecular Biology, Cell Biology, or related discipline required.
• Experience in RNA biology and mRNA translation is desirable.

Responsibilities

• Study how diet affects RNA modifications in cancer development.
• Use xenotransplantation models and multimodal profiling techniques.

Skills

Problem-solving

Organisational skills

Attention to detail

Collaboration

Bioinformatics skills

Education

PhD in Molecular Biology

PhD in Cell Biology

PhD in Pharmacy

Tools

CRISPR-screen

Ribo-seq

RNA-seq

Nanopore-seq

Job description

Postdoctoral Scientist – RNA dynamics in cancer

Location: Cancer Research UK Manchester Institute

Job Ref: MI/24/58_2

Deadline: 07 May 2025

Salary: £37,000 to £44,852 (dependent upon qualifications and experience)

Duration: 3 years fixed term (in the first instance) extended up to a total of 5 years, subject to successful review at Year 3

About the role:

A postdoctoral position is available in the laboratory of Sylvain Delaunay to study how diet affects RNA modifications to drive the development of metastasis.

To this end, xenotransplantation models and multimodal molecular profiling techniques will be used, combined with diverse bioinformatics approaches, centred around RNA biology (i.e., CRISPR-screen, Ribo-seq, RNA-seq, Nanopore-seq). Besides biological material coming from primary cell lines and in vivo mouse models, we will also have access to patient samples to use as discovery and validation of our findings.

About you:

You are adept at problem-solving, working proactively, and meeting competing deadlines effectively. You should hold a PhD in Molecular Biology, Cell Biology, Pharmacy or a related discipline. A background in RNA biology and mRNA translation is desirable but not required. You should have an excellent academic track record for publications. You will have excellent organisational skills, strong attention to detail, and the ability to work collaboratively as part of a team. A current or previous holder of a Personal Licence (PIL A & B) or equivalent under the Animals (Scientific Procedures) Act 1986, as well as experience in CRISPR-screen is preferable. Applications from candidates with exceptional bioinformatics skills who are eager to gain hands-on wet lab experience are also welcome.

How to apply?

To apply for this position please visit our website. Please note this vacancy will close for applications at 11:59pm on the closing date specified.

Closing date: 7 May 2025

Online Interviews will take place: 19th-23rd of May 2025