Postdoctoral Researcher

TN United Kingdom; Norwich; On-site; GBP 35,000 - 55,000; Full time

Job summary

An established research institute is seeking a Postdoctoral Researcher in Natural Products Chemical Biology. This exciting role focuses on unlocking the biosynthetic potential of Actinomycete bacteria, which are known for their pharmaceutical and agrochemical capabilities. The successful candidate will work closely with leading professors, conducting cutting-edge research that contributes to the discovery of new antibiotics and natural products. This position offers a unique opportunity to engage in world-class research and collaborate with a diverse team, making significant contributions to the field of chemical biology.

Qualifications

• PhD in Biological Chemistry or equivalent required.
• In-depth knowledge of natural products chemistry and biology.

Responsibilities

• Identify and modify experiments to meet project objectives.
• Prepare results and manuscripts for publication.
• Collaborate on original research and grant applications.

Skills

Natural Products Chemistry

Streptomyces Microbiology

Mass Spectrometry (MS)

Nuclear Magnetic Resonance (NMR)

Protein Purification

Microbial Molecular Genetics

Bioinformatics

Scientific Writing

Oral Research Presentations

Collaboration Skills

Education

PhD in Biological Chemistry

BSc in Chemistry or Biochemistry

Job description

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Applications are invited for a Postdoctoral Researcher in Natural Products Chemical Biology to join the laboratories of Professors Barrie Wilkinson and Matt Hutchings at the John Innes Centre based in Norwich, UK.

Actinomycete bacteria make numerous specialised metabolites (SMs), many of which have pharmaceutical and agrochemical potential. Our proposal focuses on using newly discovered genetic methods for unlocking the biosynthesis of the estimated 90% of their SMs that are genome encoded but not produced under laboratory conditions. Actinomycete SMs already account for 50% of all known antibiotics and genome sequencing has indicated there are many more waiting to be discovered. The Postdoctoral Researcher will be responsible for accessing the hidden chemical potential of unique Streptomyces species, deciphering the resulting natural products chemistry, and delineating their biosynthesis.

Key Relationships

Barrie Wilkinson (line manager), Matt Hutchings (CoI), Wilkinson & Hutchings group members (especially PDRA in Hutchings lab working on this project), and, as necessary, other researchers, research support staff and students across the Institute.

Main Activities & Responsibilities

Identify, plan, carry out and modify experiments to meet the objectives of the projectPrepare results, reports and manuscripts for publication in leading scientific journals and other relevant mediaCollaborate with colleagues within the Institute in the development of original and world-class research, including contributing to research proposals and grant applicationsAs agreed with the line manager, any other duties commensurate with the nature of the post, for example, contributing to the work of Institute committeesContribute to the smooth running of the group, including the effective use of resources, supervision of visitors to the laboratory and assisting with training others, encouraging scientific excellenceContinually strive for excellence, seeking out and acting on feedback and relevant learning and development opportunitiesDisseminate research findings through presentations to various audiences at internal, national and international meetings

Job Description

Main Purpose of the Job

Applications are invited for a Postdoctoral Researcher in Natural Products Chemical Biology to join the laboratories of Professors Barrie Wilkinson and Matt Hutchings at the John Innes Centre based in Norwich, UK.

Actinomycete bacteria make numerous specialised metabolites (SMs), many of which have pharmaceutical and agrochemical potential. Our proposal focuses on using newly discovered genetic methods for unlocking the biosynthesis of the estimated 90% of their SMs that are genome encoded but not produced under laboratory conditions. Actinomycete SMs already account for 50% of all known antibiotics and genome sequencing has indicated there are many more waiting to be discovered. The Postdoctoral Researcher will be responsible for accessing the hidden chemical potential of unique Streptomyces species, deciphering the resulting natural products chemistry, and delineating their biosynthesis.

Key Relationships

Barrie Wilkinson (line manager), Matt Hutchings (CoI), Wilkinson & Hutchings group members (especially PDRA in Hutchings lab working on this project), and, as necessary, other researchers, research support staff and students across the Institute.

Main Activities & Responsibilities

Identify, plan, carry out and modify experiments to meet the objectives of the projectPrepare results, reports and manuscripts for publication in leading scientific journals and other relevant mediaCollaborate with colleagues within the Institute in the development of original and world-class research, including contributing to research proposals and grant applicationsAs agreed with the line manager, any other duties commensurate with the nature of the post, for example, contributing to the work of Institute committeesContribute to the smooth running of the group, including the effective use of resources, supervision of visitors to the laboratory and assisting with training others, encouraging scientific excellenceContinually strive for excellence, seeking out and acting on feedback and relevant learning and development opportunitiesDisseminate research findings through presentations to various audiences at internal, national and international meetings
As agreed with line manager, any other duties commensurate with the nature of the role

Person Profile

Education & Qualifications

RequirementPhD (full award or expected within 6 months) or equivalent in Biological ChemistryBSc or equivalent in Chemistry or Biochemistry

Specialist Knowledge & Skills

RequirementIn-depth knowledge of natural products chemistry and biology, especially structure elucidationIn-depth knowledge of streptomyces microbiologyUse of MS for complex structure determinationUse of NMR for complex structure determinationProtein purificationMicrobial molecular geneticsBioinformatics skills

Relevant Experience

RequirementExperience of oral research presentationsProven record in scientific writingDemonstrated ability to perform research and develop novel ideas in natural product function and chemical ecologyExperience of supervising, training and mentoring visitors and studentsPreparing data / information for grant proposals

Interpersonal & Communication Skills

RequirementAbility to collaborate with internal and external stakeholdersAbility to follow instructions/Standard Operating ProceduresDemonstrated ability to work independently, using initiative and applying problem solving skillsExcellent time management and organisational skillsExcellent communication skills, both written and oral, including the ability to present complex information with clarity Promotes and strives for continuous improvementGood interpersonal skills, with the ability to work as part of a team

Additional Requirements

RequirementAbility to undertake occasional travel (national and international) related to collaborations and/or seminars (reasonable adjustments will be considered).Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to workAbility to maintain confidentiality and security of information where appropriate Willingness to work outside standard working hours when required Attention to detailAble to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute Promotes equality and values diversity