Postdoctoral Research Scientist in Membrane Protein Structural Biology and Protein Acylation

University of Oxford; Oxford; On-site; GBP 30,000 - 45,000; Full time

Job summary

The University of Oxford is seeking a highly motivated Postdoctoral Research Scientist in Membrane Protein Structural Biology and Protein Acylation. This role involves contributing to a multidisciplinary project, performing experimental design, and collaborating with leading institutions across the UK. Candidates should possess a PhD/DPhil and relevant expertise in structural biology, especially with membrane proteins.

Benefits

Access to top-tier cryo-EM facilities

Collaboration opportunities with leading institutions

Qualifications

• PhD/DPhil in relevant fields required.
• Experience in structural biology, particularly with membrane proteins.

Responsibilities

• Experimental design and data interpretation.
• Contribute to publications and research reports.
• Collaborate with national and international research teams.

Skills

Structural biology of membrane proteins

Cryo-EM

Data interpretation

Mammalian cell culture

Education

PhD/DPhil in chemistry, biology, or related field

Job description

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Postdoctoral Research Scientist in Membrane Protein Structural Biology and Protein Acylation, Oxford

Client:

University of Oxford

Location:

Oxford, United Kingdom

Job Category:

Other

EU work permit required:

Yes

Job Reference:

d2f2acd83f42

Job Views:

6

Posted:

25.06.2025

Expiry Date:

09.08.2025

Job Description:

We are seeking a highly motivated Postdoctoral Research Scientist to join the laboratory of Professor Christian Siebold at the University of Oxford. You will contribute to the BBSRC-funded Strategic Longer and Larger (sLoLa) research programme entitled “An integrated analysis of S-acylation dynamics and its importance in cell physiology.” This multidisciplinary project is led by the University of Strathclyde and involves leading institutions across the UK. Responsibilities include experimental design, data interpretation, dissemination of results through publications and presentations, and contributing to research reports and funding proposals. The ideal candidate holds a PhD/DPhil in chemistry, biology, or a related field, with experience in structural biology of membrane proteins using cryo-EM, including data collection, processing, and structure solution. Experience in mammalian cell culture expression and production of membrane proteins is desirable. This role offers the opportunity to work with state-of-the-art facilities and collaborate nationally and internationally.

• Work within a leading structural biology team focusing on membrane protein complexes, signalling, and receptor pharmacology.
• Benefit from access to top-tier cryo-EM facilities and collaborations across the UK, including the UK Diamond Light Source synchrotron and Imperial College London.
• Target fundamental mechanisms with translational relevance to cancer, heart diseases, and neurological disorders.