Postdoctoral Research Scientist

University of Oxford; Oxford; On-site; GBP 32,000 - 46,000; Full time

Job summary

The University of Oxford is seeking a Postdoctoral Research Scientist to join an internationally recognised programme investigating novel mechanisms of oxygen sensing and hypoxia biology. The successful candidate will contribute to a project examining cardiovascular responses to hypoxia mediated by an oxygen-sensing pathway in our lab, integrating molecular mechanisms with whole-animal physiology.

The role involves in vivo and ex vivo approaches, phenotyping of knockout models, and collaboration

Qualifications

• PhD/DPhil in cardiovascular science or closely related subject.
• Experience in management of recombinant/transgenic mouse colonies.
• Ability to manage own academic research and associated activities independently.

Responsibilities

• Manage own academic research and associated administrative activities.
• Test hypotheses and analyse scientific techniques and experimental protocols.
• Manage recombinant/transgenic in‑vivo lines.
• Analyse cardiovascular responses to hypoxia and/or stimuli in vivo and ex vivo.
• Advise group members on protocols and techniques.
• Represent the group at external meetings or seminars.
• Conduct detailed phenotyping of ADO knockout in vivo to define cardiovascular consequences of the oxygen-sensing pathway.

Skills

Independent researcher

In vivo work

Ex vivo analysis

Education

PhD/DPhil in cardiovascular science or related

Tools

Transgenic mouse colonies management

Job description

Position Summary

We are seeking an enthusiastic and talented Postdoctoral Research Scientist to join a internationally recognised programme investigating novel mechanisms of oxygen sensing and hypoxia biology. The successful candidate will contribute to a project examining cardiovascular responses to hypoxia mediated by a recently discovered oxygen‑sensing pathway first elucidated in our laboratory. This work revealed a novel mechanism whereby N‑terminal cysteine dioxygenation of the Regulators of G‑protein Signalling 4 and 5 (RGS4 and RGS5) couples cellular oxygen availability to the control of G‑protein signalling. The project will focus on defining the cardiovascular consequences of disrupting this pathway through detailed phenotyping of ADO knockout in vivo and will involve a range of in‑vivo and ex‑vivo approaches to investigate cardiovascular function under basal conditions and in response to hypoxia and/or pharmacological stimulation. The role offers an excellent opportunity to integrate molecular mechanisms of oxygen sensing with whole‑animal physiology and cardiovascular biology.

Responsibilities

• Manage own academic research and associated administrative activities.
• Test hypotheses and analyse scientific techniques and experimental protocols.
• Manage recombinant/transgenic in‑vivo lines.
• Analyse integrated cardiovascular responses to hypoxia and/or agonist stimulation in intact in‑vivo (live and unconscious) and isolated tissues ex‑vivo.
• Act as a source of information and advice to other group members on scientific protocols and experimental techniques.
• Represent the research group at external meetings or seminars, either with other group members or alone.
• Conduct detailed phenotyping of ADO knockout in vivo to define cardiovascular consequences of disrupting the oxygen‑sensing pathway.

Qualifications

• Hold a PhD/DPhil (or close to completion) in cardiovascular science or a closely related subject.
• Possess sufficient specialist knowledge in the discipline to work within established research programmes.
• Have experience in management of recombinant/transgenic mouse colonies.
• Demonstrate the ability to manage own academic research and associated activities independently.