Postdoctoral Research Associate in Structural Mass Spectrometry

University-of-Oxford; Oxford; In loco; GBP 40.000 - 45.000; Tempo pieno

Vantaggi offerti da questo lavoro

Pension scheme

38 days annual leave

Childcare services

Family leave schemes

Social clubs

Discounted travel

Descrizione del lavoro

University of Oxford in Oxford seeks a Postdoctoral Research Associate to lead native mass spectrometry work on solute carrier transporters within Biochemistry and Kavli Institute for Nanoscience. The role reports to the PI and Senior Scientist and focuses on structure and cellular biology in mammalian cells.

The successful candidate will have a PhD in a related field and strong experience in native MS, sample prep, and data analysis with Python.

Competenze

• The candidate will hold, or be near completion of, a PhD/DPhil in biophysical chemistry, analytical chemistry, structural biology or related discipline.
• Experience in native MS, sample prep, fragmentation techniques and analysis of protein modifications is required.
• Proven publication record and Python experience are advantageous.

Mansioni

• Lead the group's native mass spectrometry research for SLC transporters.
• Collaborate with PI and senior scientists in the Kavli Institute for Nanoscience.
• Develop computational analysis and potentially software in Python.

Conoscenze

Native top‑down MS

Orbitrap UHMR

Python

Proteomics

Lipidomics

Membrane protein expression

Formazione

PhD / DPhil in Biophysical or Analytical Chemistry

Strumenti

High-resolution MS software

Descrizione del lavoro

Postdoctoral Research Associate in Structural Mass Spectrometry

Dorothy Crowfoot Hodgkin Building, Biochemistry Department, South Parks Road, Oxford, OX1 3QU

Department of Biochemistry

Pay Scale: STANDARD RESEARCH GRADE 7

Location: Department of Biochemistry, South Parks Road, Oxford

Contract type: Fixed Term Contract for up to 12 months in the first instance

Hours: Full Time (37.5 hours per week)

About the role

Reporting to Professor Simon Newstead (Principal Investigator) and Dr Jo Parker (Senior Research Scientist), the post holder will be a member of the Newstead group in the Department of Biochemistry and Kavli Institute for Nanoscience, which studies the structure, mechanism and cellular biology of solute carrier (SLC) transporters. The post holder will lead the group's native mass spectrometry research, a discrete area within a larger programme on how SLC transporters are folded, modified, trafficked and regulated in mammalian cells.

This full-time fixed-term post is funded by the Wellcome Trust for up to 12 months in the first instance.

The actual starting salary offered will be based on qualifications and relevant skills acquired and will also be determined by the funding available.

About you

You will hold, or be near completion of, a PhD/DPhil in biophysical chemistry, analytical chemistry, structural biology or a related discipline, with substantial experience in native top-down mass spectrometry using high-resolution hybrid Orbitrap instrumentation, including Thermo Fisher Orbitrap UHMR and Ascend platforms. You will demonstrate expertise in native mass spectrometry sample preparation, advanced fragmentation techniques, quantitative analysis of protein modifications and lipid interactions, alongside experience in proteomics, lipidomics and membrane protein expression and purification. You will also possess strong computational and data-analysis skills, including scientific software development, ideally using Python. Experience in SLC transporter research, glycoproteomics and open-source software development, together with a strong publication record, would be advantageous.

What We Offer

Your happiness and wellbeing at work matters to us, so we offer a range of family-friendly and financial benefits including:

• An excellent contributory pension scheme
• 38 days annual leave
• A comprehensive range of childcare services
• Family leave schemes
• Membership to a variety of social and sports clubs
• Discounted bus travel and Season Ticket travel loans

The University also runs a large number of social groups and sports clubs for those looking for more than just a great place to work.

Committed to equality and valuing diversity

The closing date for applications is 12.00 noon on Monday 9th November 2026. Only applications received before this time can be considered. Interviews for shortlisted candidates to be held as soon as possible thereafter.