Postdoctoral Research Associate in Mechanisms of Cell Signalling

TN United Kingdom; Oxford; On-site; GBP 41,000 - 47,000; Full time

Job summary

An established industry player is seeking a talented Postdoctoral Research Associate to explore the intricate mechanisms of the Wnt/beta-catenin signalling pathway. This exciting opportunity involves a multidisciplinary approach, combining biochemistry, biophysics, and cell biology to advance our understanding of cellular signaling. The successful candidate will engage in cutting-edge research, utilizing advanced techniques such as CRISPR and super-resolution microscopy. With a supportive environment and generous benefits, this role promises to be a rewarding step in your academic career, allowing you to contribute significantly to groundbreaking research in cell signalling.

Benefits

Excellent contributory pension scheme

38 days annual leave

Childcare services

Family leave schemes

Cycle loan scheme

Membership to social and sports clubs

Discounted bus travel and Season Ticket loans

Qualifications

• PhD/DPhil in Biochemistry or Cell Biology, or nearing completion.
• Substantial experience in molecular biology techniques and mammalian cell culture.

Responsibilities

• Investigate molecular mechanisms driving Wnt/beta-catenin signalling pathway.
• Study regulation and recruitment of cytoplasmic signal transduction proteins.

Skills

Cell Signalling Pathways

Protein Biochemistry

In Vitro Cell Biology

Molecular Biology Techniques

Recombinant DNA

Protein Expression and Purification

Biochemical/Biophysical Characterization

Mammalian Cell Culture

Communication Skills

Organizational Skills

Education

PhD/DPhil in Biochemistry

PhD/DPhil in Cell Biology

Tools

CRISPR

Super-Resolution Microscopy

In Vitro Protein Reconstitution

Job description

Postdoctoral Research Associate in Mechanisms of Cell Signalling, Oxford

Client: University of Oxford

Location: Oxford, United Kingdom

Job Category: Other

EU work permit required: Yes

Job Reference: fcfde073f9f2

Job Views: 2

Posted: 08.05.2025

Expiry Date: 22.06.2025

Job Description:

The Dorothy Crowfoot Hodgkin Building, Biochemistry Department, South Parks Road, Oxford, OX1 3QU

Pay Scale: STANDARD RESEARCH GRADE 7

Salary (£): £41,997 - £46,913 per annum

Location: Department of Biochemistry, South Parks Road, Oxford

Contract type: Fixed Term Contract for up to 3 years

Hours: Full Time (37.5 hours per week)

About the role

The Ranes lab is seeking a talented Postdoctoral Research Associate to investigate the molecular mechanisms driving the Wnt/beta-catenin signalling pathway at the plasma membrane. The lab uses a multidisciplinary approach spanning biochemistry, biophysics, cell biology, and structural biology. You will build on previous success in biochemical reconstitution of the beta-catenin destruction complex to study Wnt pathway activation and termination using in vitro and cell-based approaches.

This role requires expertise in cell signalling pathways, protein biochemistry, and in vitro cell biology. Responsibilities include studying regulation and recruitment of cytoplasmic signal transduction proteins to Wnt receptor complexes using advanced tools such as in vitro protein reconstitution, CRISPR, and super-resolution microscopy. This full-time fixed-term post is funded by the Wellcome Trust for up to 3 years, with salary based on qualifications and skills.

What We Offer

• Excellent contributory pension scheme
• 38 days annual leave
• Childcare services
• Family leave schemes
• Cycle loan scheme
• Membership to social and sports clubs
• Discounted bus travel and Season Ticket loans

About you

You should hold a PhD/DPhil or be near completion in Biochemistry, Cell Biology, or related disciplines, with substantial experience in molecular biology techniques, recombinant DNA, protein expression and purification, and biochemical/biophysical characterization. Experience in mammalian cell culture and cell-based techniques is essential. Strong organizational skills, the ability to prioritize and multitask, and excellent communication skills are required.

Application Process