Postdoctoral Research Associate (Computational Vaccine Discovery)

LGBT Jobs; Liverpool; Hybrid; GBP 41,000 - 47,000; Full time

Benefits offered by this job

Career growth

Wellbeing initiatives

30 days annual leave

Pension schemes

Cycle to work

Sports centre membership

Job summary

Liverpool School of Tropical Medicine invites applications for a Postdoctoral Research Associate (Computational Vaccine Discovery) in Liverpool. The role focuses on turning vaccine design complexity into a usable decision platform, with emphasis on T-cell antigen prioritisation and large-scale computational pipelines.

The successful candidate will collaborate with MalariaGEN, develop scalable workflows, and contribute to publications; hybrid work 3 days on site.

Qualifications

• PhD in a quantitative or life-science discipline or equivalent experience.
• Strong programming skills, preferably in Python, with software-engineering practices.
• Experience with large, complex biological datasets and ML methods.
• Experience building reproducible workflows and analytical pipelines, ideally on HPC or cloud.
• Knowledge of relational databases and modern analytics tools is advantageous.

Responsibilities

• Build scalable, documented workflows for malaria peptide evaluation, MHC predictions, multi-omics integration and candidate-set optimisation.
• Integrate evidence with population coverage, parasite variation and expression to calibrate predictions.
• Develop scoring, filtering and optimisation approaches to enable experimental decision-making.
• Produce reusable pipelines, datasets, databases, and technical documentation for collaboration and publication.

Skills

Python

Machine learning

Data analysis

HPC

Software engineering

Education

PhD in a relevant field

Tools

DuckDB

SQL

Job description

Postdoctoral Research Associate (Computational Vaccine Discovery)

Location: Liverpool, UK

Highlighted points for this job

£40,704- £46,970 per annum salary range

Full-time, fixed-term contract for 12 months

Location: Liverpool with hybrid working arrangement

Interdisciplinary malaria research programme at the Liverpool School of Tropical Medicine

Opportunities for career growth and learning and development

Requirement of a PhD in a relevant quantitative or life-science discipline

Need for strong programming skills, preferably in Python

Postdoctoral Research Associate (Computational Vaccine Discovery)
Salary: £40,704- £46,970 per annum
Contract: Full time, Fixed term for 12 month
Location: Liverpool (Hybrid, 3 days per week on site)

We are recruiting a curious, rigorous and delivery-minded scientist to help turn the complexity of vaccine design into a usable decision platform. Malaria remains one of the world’s most important infectious diseases, but the search space for new peptide-based vaccines is enormous. A single parasite proteome can generate millions of possible peptides, and the strongest candidates must satisfy multiple constraints simultaneously

You will join an interdisciplinary malaria research programme at the Liverpool School of Tropical Medicine and work within the MalariaGEN team, collaborating with international vaccine researchers and making use of large-scale computational resources. The initial focus will be T-cell antigen and peptide prioritisation, with opportunities to contribute to broader computational antigen discovery as the programme develops.

You will help shape the computational architecture, scientific methods and evidence model behind a platform designed to support real experimental decision-making. The role combines research with software and data engineering, alongside close collaboration with vaccine scientists. It offers the opportunity to build something ambitious yet practical at the intersection of malaria genomics, immunology, machine learning and translational vaccine research.

You can learn more about this opportunity by reading our blog post about the project, as well as exploring some of our previous work in this area.

In this role, you will have the opportunity to:

• Build the core decision platform at scale. Develop scalable, tested and documented local and cloud workflows for malaria peptide evaluation, MHC class I and II predictions, multi-omics integration, ranking and candidate-set optimisation across very large datasets.
• Integrate evidence and improve prediction. Combine antigen-presentation methods with HLA population coverage, parasite variation, conservation, expression, and other evidence layers while calibrating predictions with experimental data and quantifying model uncertainty and disagreement.
• Turn data and experiments into decisions. Develop transparent scoring, filtering and optimisation approaches that help collaborators compare candidates and design experimentally tractable peptide sets; ingest assay results, assess prediction performance and iteratively improve prioritisation methods.
• Collaborate and create reusable research outputs. Work with international collaborators to provide analyses, technical support and help with scientific interpretation, while producing reusable pipelines, structured datasets and databases, technical documentation, scientific reports, presentations and peer-reviewed publications.

The successful candidate will have:

• A PhD in a relevant quantitative or life-science discipline, or equivalent substantial experience delivering advanced computational research or data-science projects.
• Strong programming skills, preferably in Python, together with sound software-engineering practices.
• Experience analysing or managing large, complex biological, biomedical or similarly high-dimensional datasets.
• Experience with statistical analysis, machine learning, quantitative method development and model evaluation.
• Experience building reproducible workflows and analytical pipelines, ideally using HPC or cloud computing environments.

It would be useful if you also have experience in one or more of:

• Proteomics, transcriptomics, single-cell or lifecycle-stage expression data, multi-omics integration, or biological knowledge graphs.
• Experience with relational database design, SQL, and modern analytical database technologies (particularly DuckDB), including building large, well-structured, queryable data resources for scientific research.
• Protein sequence or structure methods, protein language models, structural bioinformatics, or machine-learning approaches for protein and peptide analysis.

(For a full list of essential and desirable criteria please refer to the job description and person specification)

Additional benefits of joining LSTM:

• Access to support for your career growth through a variety of internal and external learning and development opportunities
• Employee Assistance Platform offering a range of wellbeing initiatives and support, in addition to high-street discount offers
• 30 days annual leave, plus 8 UK bank holidays, in addition to 6 Christmas closure days
• Generous occupational pension schemes including USS (Universities Superannuation Scheme) and NHS pension schemes (subject to eligibility)
• Government backed "cycle to work" scheme
• Affiliated, discounted staff membership to the University of Liverpool Sports Centre
• A range of enhanced family friendly policies

Candidates will be invited to complete a practical data challenge before a screening interview

Due to the volume of applications we receive, we may sometimes close our vacancies early. It is therefore advisable to apply as early as possible if you would like to be considered for a role.