Postdoctoral Fellow: Pol II Transcription & RNA Processing

University of Sussex; Falmer; On-site; GBP 39,000 - 46,000; Full time

Job summary

University of Sussex invites applications for a Postdoctoral Fellow to investigate how phosphorylation regulates RNA polymerase II transcription, RNA processing, and gene expression. The project spans biochemistry, structural biology, cell biology and functional genomics, offering scope to develop your own ideas within a collaborative environment.

The role involves maintaining mammalian cell culture, generating degron-tagged cell lines, and applying transcriptomic and biochemical analyses to

Qualifications

• Must have strong background in mammalian cell biology and biochemical approaches.
• Experience with genome editing and functional genomics techniques is essential.
• Familiarity with transcription by RNA polymerase II and RNA processing is expected.
• Practical knowledge of structural biology or quantitative proteomics is advantageous.

Responsibilities

• Maintain mammalian cell culture and generate degron-tagged cell lines.
• Apply state-of-the-art transcriptome analyses and reconstitute transcription in vitro.
• Develop and combine experimental approaches to address molecular mechanisms.
• Contribute to a collaborative, multidisciplinary research program and generate new ideas.

Skills

Pol II transcription

Mammalian culture

Genome editing

Biochemistry

Functional genomics

Genome-wide approaches

Structural biology

Quantitative proteomics

Job description

University of Sussex invites applications for a Postdoctoral Fellow to investigate how phosphorylation regulates RNA polymerase II transcription, RNA processing, and gene expression. The project spans biochemistry, structural biology, cell biology and functional genomics, offering scope to develop your own ideas within a collaborative environment.

The role involves maintaining mammalian cell culture, generating degron-tagged cell lines, and applying transcriptomic and biochemical analyses to