Postdoctoral Fellow in Computational Modelling of NeuroImmune Mechanisms of Neurodegeneration ([...]

European Commission; United Kingdom; Hybrid; GBP 36,000 - 43,000; Full time

Job summary

The European Commission seeks a Postdoctoral Fellow in Computational Modelling to work on the NeuroImmune Open Targets project. The role involves developing computational pipelines for analyzing complex datasets related to neurodegenerative diseases, contributing to impactful research and publications.

Benefits

30 days annual leave plus bank holidays

Monthly family/marriage allowance

Private medical insurance

Relocation package

On-site nursery

Qualifications

• Evidence of productive computational research.
• Experience with single-cell and spatial data analysis workflows.
• A track record of (co)first-author publications.

Responsibilities

• Analyze large-scale single-cell datasets to identify multi-cellular pathological features.
• Develop statistical and machine-learning methods for cell-cell signaling.
• Write up results for high-impact publications and present at conferences.

Skills

Statistical modelling

Coding in R

Coding in Python

Data analysis

Education

PhD in a relevant field

Job description

Organisation/Company EMBL-EBI - European Bioinformatics Institute Research Field Biological sciences Biological sciences » Biology Medical sciences » Medicine Technology » Biotechnology Computer science Mathematics » Statistics Researcher Profile Recognised Researcher (R2) Country United Kingdom Application Deadline 20 Jul 2025 - 21:59 (UTC) Type of Contract Permanent Job Status Full-time Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Postdoctoral Fellow in Computational Modelling of NeuroImmune Mechanisms of Neurodegeneration (Open Targets)
EMBL-EBI - European Bioinformatics Institute
Hinxton, United Kingdom
Your role

As a Postdoctoral Fellow on the NeuroImmune Open Targets project, you will develop and apply integrative computational pipelines to dissect immune-cell phenotypes and cell–cell interactions across Alzheimer’s, Parkinson’s, and Amyotrophic lateral sclerosis patient tissues and matched induced pluripotent stem cells models.

Your group

Saez-Rodriguez Research Group in collaboration with Open-Targets

You will

• Analyze large-scale single-cell and spatial transcriptomics datasets from human brain samples to identify shared multi-cellular pathological features;
• Build and apply statistical and machine-learning methods to infer cell-cell signaling networks and causal drivers;
• Develop pipelines to compare patient-derived data with hiPSC-derived models, identifying recapitulated phenotypes and candidate intervention targets;
• Write up results for high-impact publications and present at international conferences;
• Contribute to collaborative grant proposals and supervise junior team members.

You have

• PhD in a relevant field with evidence of productive computational research;
• Hands-on experience with single-cell and spatial data analysis workflows;
• Strong statistical modelling and coding proficiency in R and/or Python;
• Ability to translate complex computational results into biological insights;
• A track record of (co)first-author publications and effective science communication.

You may also have

• Demonstrated experience with single-cell and/or spatial transcriptomics data analysis;
• Experience with network biology computational tools;
• Knowledge of immunology, especially microglial and T-cell biology;
• Background in neurodegenerative disease biology (e.g., AD, PD, ALS) and/or familiarity with polygenic risk score analyses or rare-variant genetics would also be useful.

Benefits and Contract Information

• Financial incentives: depending on circumstances, monthly family/marriage allowance of £272, monthly child allowance of £328 per child. Generous stipend reviewed yearly, pension scheme, death benefit, long-term care, accident-at-work and unemployment insurances;
• Hybrid working arrangements;
• Private medical insurance for you and your immediate family (including all prescriptions and generous dental & optical cover);
• Generous time off: 30 days annual leave per year, in addition to eight bank holidays;
• Relocation package;
• Campus life: Free shuttle bus to and from work, on-site library, subsidised on-site gym and cafeteria, casual dress code, extensive sports and social club activities (on campus and remotely);
• Family benefits: On-site nursery, child sick leave, generous parental leave, holiday clubs on campus and monthly family and child allowances;
• Contract duration: This position is a 2 year fixed term contract with possibility for renewal to a maximum of 5 years;
• Salary: Year 1 Stipend at rate of £3,307 per month after tax (Total package will be dependant on family circumstances);
• International applicants: We recruit internationally and successful candidates are offered visa exemptions. Read more on our page for international applicants ;
• Diversity and inclusion: At EMBL-EBI, we strongly believe that inclusive and diverse teams benefit from higher levels of innovation and creative thought. We encourage applications from women, LGBTQ+ and individuals from all nationalities;
• Job location: This role is based in Hinxton, near Cambridge, UK. You will be required to relocate if you are based overseas and you will receive a generous relocation package to support you;
• To apply please submit a cover letter and a CV through our online system before the closing date: 20/07/2025.